Parasites Dampen Dendritic Cell Activation to Ensure Their Survival

被引：2
作者：
von Stebut, Esther [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany
来源：
TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 02期
关键词：
LEISHMANIA-MAJOR INFECTION; IMMUNITY; MINCLE; SKIN;
D O I：
10.1016/j.pt.2016.12.001
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Dendritic cells (DCs) are critical for induction of protective immunity against Leishmania major. However, DC activation occurs only several weeks after parasite transmission. ParaSites synthesize a macrophage-inducible C-type lectin (Mincle) ligand. Engagement of Mincle by the parasite ligand dampens DC activation, thus delaying induction of interferon gamma-producing T cells responsible for parasite eradication.
引用
收藏
页码：78 / 80
页数：3
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