Phase I pharmacodynamic (PD) and pharmacokinetic (PIK) analysis of the sorafenib (S) and erlotinib (E) combination in patients with advanced solid tumors

被引：0
|
作者：
Le Tourneau, C. [1 ]
Duran, I. [1 ]
Chen, E. [1 ]
Wang, L. [2 ]
Tsao, M. [3 ]
Hedley, D. [3 ]
Phan, N. [3 ]
Do, T. [3 ]
Metser, U. [4 ]
Siu, L. [1 ]
机构：
[1] Princess Margaret Hosp, Dept Med Oncol, Drug Dev Program, Toronto, ON M4X 1K9, Canada
[2] Princess Margaret Hosp, Dept Biostat, Toronto, ON M4X 1K9, Canada
[3] Princess Margaret Hosp, Correlat Studies Dept, Toronto, ON M4X 1K9, Canada
[4] Princess Margaret Hosp, Dept Radiol, Toronto, ON M4X 1K9, Canada
来源：
EJC SUPPLEMENTS | 2008年 / 6卷 / 12期
关键词：
D O I：
10.1016/S1359-6349(08)72344-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：129 / 129
页数：1
相关论文
共 50 条
  • [21] A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Panobinostat, an HDAC Inhibitor, Combined with Erlotinib in Patients with Advanced Aerodigestive Tract Tumors
    Gray, Jhanelle E.
    Haura, Eric
    Chiappori, Alberto
    Tanvetyanon, Tawee
    Williams, Charles C.
    Pinder-Schenck, Mary
    Kish, Julie A.
    Kreahling, Jenny
    Lush, Richard
    Neuger, Anthony
    Tetteh, Leticia
    Akar, Angela
    Zhao, Xiuhua
    Schell, Michael J.
    Bepler, Gerold
    Altiok, Soner
    CLINICAL CANCER RESEARCH, 2014, 20 (06) : 1644 - 1655
  • [22] A phase I pharmacokinetic and pharmacodynamic study of GTI-2040 in combination with gemcitabine in patients with solid tumors
    Malik, Laeeq
    Zwiebel, Anthony
    Cooper, James
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2018, 82 (03) : 533 - 539
  • [23] A phase I pharmacokinetic and pharmacodynamic study of GTI-2040 in combination with gemcitabine in patients with solid tumors
    Laeeq Malik
    Anthony Zwiebel
    James Cooper
    Cancer Chemotherapy and Pharmacology, 2018, 82 : 533 - 539
  • [24] A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors
    Tabernero, Josep
    Dirix, Luc
    Schoffski, Patrick
    Cervantes, Andres
    Antonio Lopez-Martin, Jose
    Capdevila, Jaume
    van Beijsterveldt, Ludy
    Platero, Suso
    Hall, Brett
    Yuan, Zhilong
    Knoblauch, Roland
    Zhuang, Sen Hong
    CLINICAL CANCER RESEARCH, 2011, 17 (19) : 6313 - 6321
  • [25] A phase I pharmacodynamic and pharmacokinetic study of a Ras inhibitor, PRLX 93936, in patients with advanced solid tumors
    Ramanathan, R. K.
    Rosen, P. J.
    Wagner, A. J.
    Sahasrabudhe, S.
    Weiss, G. J.
    Lee, P.
    Fuerst, M.
    Robbins, P.
    Litka, P.
    Von Hoff, D. D.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
  • [26] Modulation of pharmacodynamic (PD) biomarkers in dermal biopsies from patients treated on a phase I study of bevacizumab (Bev) in combination with everolimus (Ev) and erlotinib (Erl) for advanced solid tumors
    Jia, Jingquan
    Li, Haiyan
    Dellinger, Andrew
    Pang, Herbert
    Russell, Karen Bullock
    Hurwitz, Herbert
    Nixon, Andrew B.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [27] A phase i study of ixazomib and erlotinib in patients with advanced solid tumors
    Kato, Shumei
    Adashek, Jacob J.
    Subbiah, Vivek
    Fu, Siqing
    Sun, Mianen
    Nguyen, Ly
    Brown, Elsa J.
    Yap, Timothy A.
    Karp, Daniel D.
    Piha-Paul, Sarina A.
    Hong, David S.
    INVESTIGATIONAL NEW DRUGS, 2022, 40 (01) : 99 - 105
  • [28] A phase I, pharmacokinetic and pharmacodynamic study of sorafenib (S), a multi-targeted kinase inhibitor in combination with temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies
    Patnaik, A.
    Ricart, A.
    Cooper, J.
    Papadopoulos, K.
    Beeram, M.
    Mita, C.
    Mita, M. M.
    Hufnagel, D.
    Izbicka, E.
    Tolcher, A. W.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [29] Pharmacokinetic (PK) and pharmacodynamic (PD) study of the combination of docetaxel (Doc) and oxaliplatin (Ox) in patients (Pts) with advanced solid tumors
    Zamboni, W.
    hwang, J. J.
    Strychor, S.
    Sidone, B. J.
    Zamboni, B. A.
    Malik, S. M.
    Catley, K.
    Grafton, K.
    Marshall, J. L.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [30] A phase i study of ixazomib and erlotinib in patients with advanced solid tumors
    Shumei Kato
    Jacob J. Adashek
    Vivek Subbiah
    Siqing Fu
    Mianen Sun
    Ly Nguyen
    Elsa J. Brown
    Timothy A. Yap
    Daniel D. Karp
    Sarina A. Piha-Paul
    David S. Hong
    Investigational New Drugs, 2022, 40 : 99 - 105
12345