Phase I pharmacodynamic (PD) and pharmacokinetic (PIK) analysis of the sorafenib (S) and erlotinib (E) combination in patients with advanced solid tumors

被引：0
|
作者：
Le Tourneau, C. [1 ]
Duran, I. [1 ]
Chen, E. [1 ]
Wang, L. [2 ]
Tsao, M. [3 ]
Hedley, D. [3 ]
Phan, N. [3 ]
Do, T. [3 ]
Metser, U. [4 ]
Siu, L. [1 ]
机构：
[1] Princess Margaret Hosp, Dept Med Oncol, Drug Dev Program, Toronto, ON M4X 1K9, Canada
[2] Princess Margaret Hosp, Dept Biostat, Toronto, ON M4X 1K9, Canada
[3] Princess Margaret Hosp, Correlat Studies Dept, Toronto, ON M4X 1K9, Canada
[4] Princess Margaret Hosp, Dept Radiol, Toronto, ON M4X 1K9, Canada
来源：
EJC SUPPLEMENTS | 2008年 / 6卷 / 12期
关键词：
D O I：
10.1016/S1359-6349(08)72344-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：129 / 129
页数：1
相关论文
共 50 条
  • [1] Phase I pharmacokinetic and pharmacodynamic study of lapatinib in combination with sorafenib in patients with advanced refractory solid tumors
    Simonelli, Matteo
    Zucali, Paolo A.
    Lorenzi, Elena
    Rubino, Luca
    De Vincenzo, Fabio
    De Sanctis, Rita
    Perrino, Matteo
    Mancini, Luca
    Di Tommaso, Luca
    Rimassa, Lorenza
    Masci, Giovanna
    Zuradelli, Monica
    Suter, Matteo B.
    Bertossi, Monica
    Fattuzzo, Giuseppe
    Giordano, Laura
    Roncalli, Massimo G.
    Santoro, Armando
    EUROPEAN JOURNAL OF CANCER, 2013, 49 (05) : 989 - 998
  • [2] Phase I, pharmacokinetic (PK), pharmacodynamic (PD) study of lapatinib (L) in combination with sorafenib (S) in patients with advanced refractory solid tumors.
    Simonelli, M.
    Zucali, P. A.
    De Sanctis, R.
    Lorenzi, E.
    De Vincenzo, F.
    Rimassa, L.
    Tronconi, M. C.
    Personeni, N.
    Masci, G.
    Zuradelli, M.
    Perrino, M.
    Bertossi, M.
    Giordano, L.
    Santoro, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [3] Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
    Duran, Ignacio
    Hotte, Sebastien J.
    Hirte, Holger
    Chen, Eric X.
    MacLean, Martha
    Turner, Sandra
    Duan, Lixia
    Pond, Gregory R.
    Lathia, Chetan
    Walsh, Scott
    Wright, John J.
    Dancey, Janet
    Siu, Lillian L.
    CLINICAL CANCER RESEARCH, 2007, 13 (16) : 4849 - 4857
  • [4] Phase I Combination of Sorafenib and Erlotinib Therapy in Solid Tumors: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation from an Expansion Cohort
    Quintela-Fandino, Miguel
    Le Tourneau, Christophe
    Duran, Ignacio
    Chen, Eric X.
    Wang, Lisa
    Tsao, Ming
    Bandarchi-Chamkhaleh, Bizhan
    Pham, Nhu-Ann
    Do, Trevor
    MacLean, Martha
    Nayyar, Rakesh
    Tusche, Michael W.
    Metser, Ur
    Wright, John J.
    Mak, Tak W.
    Siu, Lillian L.
    MOLECULAR CANCER THERAPEUTICS, 2010, 9 (03) : 751 - 760
  • [5] Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors
    Erich Brendel
    Matthias Ludwig
    Chetan Lathia
    Caroline Robert
    Stanislas Ropert
    Jean-Charles Soria
    Jean-Pierre Armand
    Cancer Chemotherapy and Pharmacology, 2011, 68 : 53 - 61
  • [6] Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors
    Brendel, Erich
    Ludwig, Matthias
    Lathia, Chetan
    Robert, Caroline
    Ropert, Stanislas
    Soria, Jean-Charles
    Armand, Jean-Pierre
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 68 (01) : 53 - 61
  • [7] Phase I, Pharmacokinetics (PK), Pharmacodynamic (PD) Study of Lapatinib (L) in Combination With Sorafenib (S) in Patients With Advanced Refractory Solid Tumours
    Simonelli, M.
    Zucali, P. A.
    De Sanctis, R.
    Lorenzi, E.
    De Vincenzo, F.
    Rimassa, L.
    Tronconi, M. G.
    Zuradelli, M.
    Giordano, L.
    Santoro, A.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S159 - S159
  • [8] A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors
    Fakih, Marwan G.
    Trump, Donald L.
    Muindi, Josephia R.
    Black, Jennifer D.
    Bernardi, Ronald J.
    Creaven, Patrick J.
    Schwartz, James
    Brattain, Michael G.
    French, Renee
    Johnson, Candance S.
    CLINICAL CANCER RESEARCH, 2007, 13 (04) : 1216 - 1223
  • [9] A Phase I study of sorafenib in combination with capecitabine in patients with advanced, solid tumors
    Awada, A.
    Gil, T.
    Burk, K.
    Vanhamme, J.
    Mancini, I.
    Besse, T.
    Brendel, E.
    Matthys, A.
    Piccart, M.
    Hendlisz, A.
    EJC SUPPLEMENTS, 2006, 4 (12): : 33 - 34
  • [10] A phase I, pharmacokinetic and pharmacodynamic study of nimotuzumab in Japanese patients with advanced solid tumors
    Wataru Okamoto
    Takayuki Yoshino
    Toshiaki Takahashi
    Isamu Okamoto
    Shinya Ueda
    Asuka Tsuya
    Narikazu Boku
    Kazuto Nishio
    Masahiro Fukuoka
    Nobuyuki Yamamoto
    Kazuhiko Nakagawa
    Cancer Chemotherapy and Pharmacology, 2013, 72 : 1063 - 1071
12345