Discovery of antibiotic adjuvants

被引：42

作者：

Farha, Maya A. ^{[1
,2
]}

Brown, Eric D. ^{[1
,2
]}

机构：

[1] McMaster Univ, MG DeGroote Inst Infect Dis Res, Hamilton, ON, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

来源：

NATURE BIOTECHNOLOGY | 2013年 / 31卷 / 02期

关键词：

INFECTIONS; MECHANISM; DRUGS;

D O I：

10.1038/nbt.2500

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Modeling the production of reactive oxygen species in bacteria reveals targets for adjuvants that boost antibiotic activity.

引用

页码：120 / 122

页数：3

共 11 条

[1] Metabolite-enabled eradication of bacterial persisters by aminoglycosides [J].

Allison, Kyle R. ;

Brynildsen, Mark P. ;

Collins, James J. .

NATURE, 2011, 473 (7346) :216-+

[2] Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production [J].

Brynildsen, Mark P. ;

Winkler, Jonathan A. ;

Spina, Catherine S. ;

MacDonald, I. Cody ;

Collins, James J. .

NATURE BIOTECHNOLOGY, 2013, 31 (02) :160-165

[3] Enhancing antibiotic activity: a strategy to control Acinetobacter infections [J].

Chusri, Sasitorn ;

Villanueva, Ivan ;

Voravuthikunchai, Supayang Piyawan ;

Davies, Julian .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (06) :1203-1211

[4] Combination drugs, an emerging option for antibacterial therapy [J].

Cottarel, Guillaume ;

Wierzbowski, Jamey .

TRENDS IN BIOTECHNOLOGY, 2007, 25 (12) :547-555

[5]

Ejim L, 2011, NAT CHEM BIOL, V7, P348, DOI [10.1038/NCHEMBIO.559, 10.1038/nchembio.559]

[6] Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams [J].

Farha, Maya A. ;

Leung, Alexander ;

Sewell, Edward W. ;

D'Elia, Michael A. ;

Allison, Sarah E. ;

Ejim, Linda ;

Pereira, Pedro M. ;

Pinho, Mariana G. ;

Wright, Gerard D. ;

Brown, Eric D. .

ACS CHEMICAL BIOLOGY, 2013, 8 (01) :226-233

[7] Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections [J].

Hurdle, Julian G. ;

O'Neill, Alex J. ;

Chopra, Ian ;

Lee, Richard E. .

NATURE REVIEWS MICROBIOLOGY, 2011, 9 (01) :62-75

[8] Multicomponent therapeutics for networked systems [J].

Keith, CT ;

Borisy, AA ;

Stockwell, BR .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (01) :71-U10

[9] A common mechanism of cellular death induced by bactericidal antibiotics [J].

Kohanski, Michael A. ;

Dwyer, Daniel J. ;

Hayete, Boris ;

Lawrence, Carolyn A. ;

Collins, James J. .

CELL, 2007, 130 (05) :797-810

[10] Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents [J].

Rogers, Steven A. ;

Huigens, Robert W., III ;

Cavanagh, John ;

Melander, Christian .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :2112-2118

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