Crush stenting with paclitaxel-eluting or sirolimus-eluting stents for the treatment of coronary bifurcation lesions

被引:12
作者
Chen, Shaoliang [1 ]
Zhang, Junjie [1 ]
Ye, Fei [1 ]
Zhu, Zhongsheng [1 ]
Lin, Song [1 ]
Tian, Nailiang [1 ]
Liu, Zhizhong [1 ]
Fang, Weiyi [2 ]
Chen, Yundai [3 ]
Sun, Xuewen [1 ]
Kwan, Tak W. [4 ]
机构
[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, Nanjing 210006, Peoples R China
[2] Shanghai Chest Hosp, Dept Cardiol, Shanghai, Peoples R China
[3] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China
[4] Beth Israel Deaconess Med Ctr, Dept Cardiol, New York, NY 10003 USA
关键词
coronary artery disease; percutaneous coronary intervention; bifurcation lesions;
D O I
10.1177/0003319707312519
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Two hundred forty-six patients with 252 bifurcation lesions were enrolled into a prospective, nonrandomized study to use paclitaxel-eluting or sirolimus-eluting stent for crush stenting in the treatment of coronary bifurcation lesions. Compared with the sirolimus-eluting stent group, the paclitaxel-eluting stent group had significantly higher mean late lumen and binary angiographic restenosis rates. Sirolimus-eluting stent versus paclitaxel-eluting stent recipients had significantly lower in-segment restenosis in the entire main vessel (15.7% vs 3.1%, P = .004), and simultaneous side branch and main vessel restenoses were solely detected in the paclitaxel-eluting stent group (11.9% vs 0%, P = .03). Target-lesion vessel revascularization and Cumulative major adverse cardiac events rates were significantly higher in the paclitaxel-eluting versus the sirolimus-eluting stent group (17.99% vs 8.41%, P = .01; 19.4 vs 9.3%, P = .01; 23.6 vs 11.2%, P = .03). In this study with crush stenting, use of sirolimus-eluting stent, compared with paclitaxel-eluting stent, yielded significantly lower late lumen loss, restenosis, and revascularization rates, with comparable safety by 8-month follow-up.
引用
收藏
页码:475 / 483
页数:9
相关论文
共 25 条
[1]   Immediate and one-year outcome in patients with coronary bifurcation lesions in the modern era (NHLBI Dynamic Registry) [J].
Al Suwaidi, J ;
Yeh, WL ;
Cohen, HA ;
Detre, KM ;
Williams, DO ;
Holmes, DR .
AMERICAN JOURNAL OF CARDIOLOGY, 2001, 87 (10) :1139-1144
[2]   Drug-eluting stents in bifurcation lesions: To stent one branch or both? [J].
Assali, Abid R. ;
Assa, Hana V. ;
Ben-Dor, Itsik ;
Teplitsky, Igal ;
Solodky, Alejandro ;
Brosh, David ;
Fuchs, Shmuel ;
Kornowski, Ran .
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2006, 68 (06) :891-896
[3]   Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions [J].
Colombo, A ;
Moses, JW ;
Morice, MC ;
Ludwig, J ;
Holmes, DR ;
Spanos, V ;
Louvard, Y ;
Desmedt, B ;
Di Mario, C ;
Leon, MB .
CIRCULATION, 2004, 109 (10) :1244-1249
[4]   Modified T-stenting technique with crushing for bifurcation lesions: Immediate results and 30-day outcome [J].
Colombo, A ;
Stankovic, G ;
Orlic, D ;
Corvaja, N ;
Liistro, F ;
Airoldi, F ;
Chieffo, A ;
Spanos, V ;
Montorfano, M ;
Di Mario, C .
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2003, 60 (02) :145-151
[5]   Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients [J].
Dibra, A ;
Kastrati, A ;
Mehilli, J ;
Pache, J ;
Schühlen, H ;
von Beckerath, N ;
Ulm, K ;
Wessely, R ;
Dirschinger, J ;
Schömig, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (07) :663-670
[6]   Predictors of long-term outcome after crush stenting of coronary bifurcation lesions: Importance of the bifurcation angle [J].
Dzavik, Vladimir ;
Kharbanda, Rajesh ;
Ivanov, Joan ;
Ing, Douglas J. ;
Bui, Sanh ;
Mackie, Karen ;
Ramsamujh, Rachael ;
Barolet, Alan ;
Schwartz, Leonard ;
Seidelin, Peter H. .
AMERICAN HEART JOURNAL, 2006, 152 (04) :762-769
[7]   Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents [J].
Finn, AV ;
Kolodgie, FD ;
Harnek, J ;
Guerrero, LJ ;
Acampado, E ;
Tefera, K ;
Skorija, K ;
Weber, DK ;
Gold, HK ;
Virmani, R .
CIRCULATION, 2005, 112 (02) :270-278
[8]   Clinical and angiographic outcome after implantation of drug-eluting stents in bifurcation lesions with the crush stent technique - Importance of final kissing balloon post-dilation [J].
Ge, L ;
Airoldi, F ;
Iakovou, I ;
Md, JC ;
Michev, I ;
Sangiorgi, GM ;
Montorfano, M ;
Chieffo, A ;
Carlino, M ;
Corvaja, N ;
Colombo, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (04) :613-620
[9]   Treatment of bifurcation lesions with two stents: one year angiographic and clinical follow up of crush versus T stenting [J].
Ge, L ;
Iakovou, I ;
Cosgrave, J ;
Agostoni, P ;
Airoldi, F ;
Sangiorgi, GM ;
Michev, I ;
Chieffo, A ;
Montorfano, M ;
Carlino, N ;
Corvaja, N ;
Colombo, A .
HEART, 2006, 92 (03) :371-376
[10]   Long-term outcomes after stenting of bifurcation lesions with the "crush" technique - Predictors of an adverse outcome [J].
Hoye, Angela ;
Iakovou, Ioannis ;
Ge, Lei ;
van Mieghem, Carlos A. G. ;
Ong, Andrew T. L. ;
Cosgrave, John ;
Sanglorgi, Giuseppe M. ;
Airoldi, Flavio ;
Montorfano, Matteo ;
Michev, Iassen ;
Chieffo, Alaide ;
Carlino, Mauro ;
Corvaja, Nicola ;
Aoki, Jiro ;
Granillo, Gaston A. Rodriguez ;
Valgimigli, Marco ;
Sianos, Georgios ;
van der Giessen, Willem J. ;
de Feyter, Pim J. ;
van Domburg, Ron T. ;
Serruys, Patrick W. ;
Colombo, Antonio .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (10) :1949-1958