SLC27 fatty acid transport proteins

被引：248

作者：

Anderson, Courtney M. ^{[1
]}

Stahl, Andreas ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 2-3期

基金：

瑞士国家科学基金会;

关键词：

SLC27; FATP; Fatty acid transport proteins; Fatty acid uptake; Fatty acid activation; ACYL-COA SYNTHETASE; THROUGHPUT SCREENING ASSAY; SACCHAROMYCES-CEREVISIAE; DIFFERENTIAL EXPRESSION; INSULIN-RESISTANCE; TARGETED DELETION; MOLECULAR-CLONING; SKELETAL-MUSCLE; CELLULAR UPTAKE; ADIPOSE-TISSUE;

D O I：

10.1016/j.mam.2012.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uptake and metabolism of long chain fatty acids (LCFA) are critical to many physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie the pathology of numerous metabolic diseases. Protein-mediated transport of LCFA has been proposed as the major mode of LCFA uptake and activation. Several proteins have been identified to be involved in LCFA uptake. This review focuses on the SLC27 family of fatty acid transport proteins, also known as FATPs, with an emphasis on the gain- and loss-of-function animal models that elucidate the functions of FATPs in vivo and how these transport proteins play a role in physiological and pathological situations. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：516 / 528

页数：13

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