Reduced water intake but normal response to acute water deprivation in elderly rhesus monkeys

被引:5
作者
Schroederus, KM [1 ]
Gresl, TA [1 ]
Kemnitz, JW [1 ]
机构
[1] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA
关键词
age differences; fluid balance; nonhuman primates; water deprivation; water intake;
D O I
10.1007/BF03399648
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The ability to compensate for acute water deprivation was studied in young adult (YA, 7-9 years), middle aged (MA, 13-17 years), and older adult (OA, 20-36 years) rhesus monkeys of both sexes (N=6/group). Water intake and urine volume were measured during three 7-day trials: 3 days of baseline measurement, 1 day of deprivation and 3 days of compensation. OA drank less during baseline (380+/-63 mL/day) than MA (679+/-92 mL/day, p<0.05) or YA (750+/-128 mL/day, p<0.01). All groups drank more following deprivation than at baseline and the OA drank significantly less than the younger groups (both p<0.01), but the increase above baseline did not differ among groups when expressed as a cumulative percentage of baseline (89% for OA; 77% for MA; 83% for YA). Urine volume of all groups decreased by similar percentages on the day of deprivation (56% overall) and this reduction represented a similar proportion (58% overall) of baseline water intake. Urine concentration increased significantly during deprivation (p<0.05) and returned to baseline values during compensation with no differences among age groups. OA water balance appears to have been maintained at lower levels of intake and excretion. In conclusion, responses to acute hydrational challenges in the elderly should be interpreted in the context of customary fluid intake.
引用
收藏
页码:101 / 108
页数:8
相关论文
共 32 条
[1]   URINARY INDEXES OF HYDRATION STATUS [J].
ARMSTRONG, LE ;
MARESH, CM ;
CASTELLANI, JW ;
BERGERON, MF ;
KENEFICK, RW ;
LAGASSE, KE ;
RIEBE, D .
INTERNATIONAL JOURNAL OF SPORT NUTRITION, 1994, 4 (03) :265-279
[2]   THE EFFECT OF AGE ON THE CONTROL OF WATER CONSERVATION IN THE LABORATORY MOUSE-METABOLIC STUDIES [J].
DAVIES, I ;
GODDARD, C ;
FOTHERINGHAM, AP ;
MOSER, B ;
FARAGHER, EB .
EXPERIMENTAL GERONTOLOGY, 1985, 20 (01) :53-66
[3]   A LONGITUDINAL-STUDY OF ESTROGEN AND CALCIUM SUPPLEMENT USE AMONG JAPANESE WOMEN LIVING IN HAWAII [J].
DAVIS, JW ;
ROSS, PD ;
WASNICH, RD .
PREVENTIVE MEDICINE, 1995, 24 (02) :159-165
[4]   MECHANISMS OF RENAL TUBULAR DEFECTS IN OLD-AGE [J].
DONTAS, AS ;
PAPANAYIOTOU, P ;
MARKETOS, SG .
POSTGRADUATE MEDICAL JOURNAL, 1972, 48 (559) :295-+
[5]  
Guyton AC., 1991, TXB MED PHYSL, V8th ed, P274
[6]  
JUDGE TG, 1978, TXB GERIATRIC MED GE, P117
[7]   CHARACTERISTICS OF SPONTANEOUS OBESITY IN MALE RHESUS-MONKEYS [J].
KEMNITZ, JW ;
FRANCKEN, GA .
PHYSIOLOGY & BEHAVIOR, 1986, 38 (04) :477-483
[8]  
KEMNITZ JW, 1917, J GERONTOL, V48
[9]   DEHYDRATION IN THE ELDERLY [J].
LEAF, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (12) :791-792
[10]   Changes with age in the renal function in adult men I. Clearance of urea. II. Amount of urea nitrogen in the blood. III. Concentrating ability of the kidneys [J].
Lewis, WH ;
Alving, AS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1938, 123 (02) :500-515