High serum levels of CA125 and interleukin-6 in a patient with Ki-1 lymphoma

被引：45

作者：

Kubonishi, I ^{[1
]}

Bandobashi, K ^{[1
]}

Murata, N ^{[1
]}

Daibata, M ^{[1
]}

Ido, E ^{[1
]}

Sonobe, H ^{[1
]}

Ohtsuki, Y ^{[1
]}

Miyoshi, I ^{[1
]}

机构：

[1] KOCHI MED SCH,DEPT PATHOL,KOCHI 783,JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 02期

关键词：

Ki-1; lymphoma; CA125; IL-6; IL-6-dependent cell line; aggressive lymphoma;

D O I：

10.1046/j.1365-2141.1997.2383054.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mie report a 53-year-old-man with an aggressive Ki-l lymphoma who had high serum CA125, a marker protein of the epithelial ovarian cancer, and interleukin-6 (IL-6) concentrations. Both CA125 and IL-6 levels decreased after chemotherapy and elevated with disease progression. The patient's lymphoma cells obtained before chemotherapy grew continuously in vitro, were IL-6 dependent and were found to secrete CA125 in culture medium. These results indicate that CA125 can be secreted by Ki-l lymphoma cells and IL-6 may promote the growth of Ki-1 lymphoma cells.

引用

页码：450 / 452

页数：3

共 10 条

[1]

APEL RL, 1995, ARCH PATHOL LAB MED, V119, P373

[2] A RADIOIMMUNOASSAY USING A MONOCLONAL-ANTIBODY TO MONITOR THE COURSE OF EPITHELIAL OVARIAN-CANCER [J].