RNA polymerase encounters with DNA damage: Transcription-coupled repair or transcriptional mutagenesis?

被引：140

作者：

Saxowsky, TT

Doetsch, PW

机构：

[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr040466q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interactions of DNA polymerases with DNA damage during replication and the contributions of these interactions to mutagenesis and genomic stability are outlined. DNA lesions are classified into two distinct categories with respect to transcription, and these are cytotoxic and mutagenic. These two DNA damages can be repaired by transcription-coupled repair (TCR) and transcriptional mutagenesis (TM), respectively. Advances to help understand the mechanisms and implications of TCR and TM in eukaryotic cells are also discussed.

引用

页码：474 / 488

页数：15

共 163 条

[31] Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesis [J].

Doetsch, PW .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2002, 510 (1-2) :131-140

[32]

DOETSCH PW, 1999, ADV DNA DAMAGE REPAI

[33] TRANSCRIPT CLEAVAGE BY RNA-POLYMERASE-II ARRESTED BY A CYCLOBUTANE PYRIMIDINE DIMER IN THE DNA-TEMPLATE [J].

DONAHUE, BA ;

YIN, S ;

TAYLOR, JS ;

REINES, D ;

HANAWALT, PC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8502-8506

[34] Effects of aminofluorene and acetylaminofluorene DNA adducts on transcriptional elongation by RNA polymerase II [J].

Donahue, BA ;

Fuchs, RPP ;

Reines, D ;

Hanawalt, PC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (18) :10588-10594

[35] Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2 [J].

Dou, H ;

Mitra, S ;

Hazra, TK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :49679-49684

[36]

Dumaz N, 1997, MOL CARCINOGEN, V20, P340, DOI 10.1002/(SICI)1098-2744(199712)20:4<340::AID-MC3>3.0.CO

[37]

2-N

[38] In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product [J].

Fitch, ME ;

Nakajima, S ;

Yasui, A ;

Ford, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (47) :46906-46910

[39] The base excision repair: mechanisms and its relevance for cancer susceptibility [J].

Fortini, P ;

Pascucci, B ;

Parlanti, E ;

D'Errico, M ;

Simonelli, V ;

Dogliotti, E .

BIOCHIMIE, 2003, 85 (11) :1053-1071

[40] DNA damage and repair [J].

Friedberg, EC .

NATURE, 2003, 421 (6921) :436-440

← 1 2 3 4 5 6 7 8 9 10 →