RNA polymerase encounters with DNA damage: Transcription-coupled repair or transcriptional mutagenesis?

被引：140
作者：
Saxowsky, TT
Doetsch, PW
机构：
[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA
来源：
CHEMICAL REVIEWS | 2006年 / 106卷 / 02期
关键词：
D O I：
10.1021/cr040466q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions of DNA polymerases with DNA damage during replication and the contributions of these interactions to mutagenesis and genomic stability are outlined. DNA lesions are classified into two distinct categories with respect to transcription, and these are cytotoxic and mutagenic. These two DNA damages can be repaired by transcription-coupled repair (TCR) and transcriptional mutagenesis (TM), respectively. Advances to help understand the mechanisms and implications of TCR and TM in eukaryotic cells are also discussed.
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页码：474 / 488
页数：15
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