Vitamin D to prevent COVID-19: recommendations for the design of clinical trials

被引：20

作者：

Camargo, Carlos A., Jr. ^{[1
]}

Martineau, Adrian R. ^{[2
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02115 USA

[2] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Populat Hlth Sci, London, England

来源：

FEBS JOURNAL | 2020年 / 287卷 / 17期

关键词：

clinical trial; COVID-19; randomized controlled trial; vitamin D;

D O I：

10.1111/febs.15534

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the potential role of vitamin D supplementation to prevent COVID-19. In this issue, Merzon and colleagues report epidemiologic data on the vitamin D status of 7807 individuals and their risk of developing COVID-19. In multivariable analyses, low vitamin D status was associated with increased risk of both COVID-19 infection and hospitalization. The authors call for clinical trials of vitamin D supplementation. In this Commentary, we discuss some of the challenges of vitamin D research and provide recommendations for the design of randomized controlled trials of vitamin D supplementation to prevent COVID-19.

引用

页码：3689 / 3692

页数：4

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