'Synthesis and Biological Assessment of Some New Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents'

A series of novel acrylonitrile derivatives 4-10 have been synthesized and characterized by spectral data. The in-vitro antitumor activity of all compounds was assessed in the MCF-7 human breast cancer cell line. The results showed that compound 8a exhibited promising anticancer activity with IC50 = 9.92 mu g/mL while, compounds 4b, 4c, 7b, 8c and 10b possessed moderate cytotoxic effect with IC50 ranging 15.64-20.76 mu g/mL. The final targets were also tested for their antimicrobial activity. The results revealed that compounds 4a, 5b, 8a and 8c showed remarkable broad spectrum antimicrobial activity, while compounds 5c, 8a and 8c displayed high antifungal activity against candida albicans compared to amphotericin B reference drug with IC50 = 9.30, 6.25 and 2.30 mu g/mL, respectively. [Azza Taher Taher. Synthesis and Biological Assessment of Some New Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents. Life Sci J 2012; 9(1): 991-1005] (ISSN:1097-8135). http://www.lifesciencesite.com. 143