Hypoxia down-regulates cyclic guanidine monophosphate-dependent protein kinase in fetal pulmonary vascular smooth muscle cell through generation of reactive oxygen species and promotes development of pulmonary hypertension

被引：6
|
作者：
Sander, F [1 ]
Gao, YS [1 ]
Raj, JU [1 ]
机构：
[1] Univ Calif Los Angeles, Ctr Med, Res & Educ Inst, Torrance, CA 90502 USA
来源：
CHEST | 2005年 / 128卷 / 06期
关键词：
D O I：
10.1378/chest.128.6_suppl.577S-a
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
引用
收藏
页码：577S / 578S
页数：2
相关论文
共 21 条
  • [1] Regulation of pulmonary vascular smooth muscle cell proliferation in the ovine fetus: Role of cyclic guanosine monophosphate-dependent protein kinase.
    Narasimhan, SR
    Negash, S
    Raj, JU
    JOURNAL OF INVESTIGATIVE MEDICINE, 2006, 54 (01) : S109 - S109
  • [2] Hypoxic Regulation of Pulmonary Vascular Smooth Muscle Cyclic Guanosine Monophosphate-Dependent Kinase by the Ubiquitin Conjugating System
    Ramchandran, Ramaswamy
    Pilipenko, Evgeny
    Bach, Laura
    Raghavan, Aarti
    Reddy, Sekhar P.
    Raj, J. Usha
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 46 (03) : 323 - 330
  • [3] Cyclic Guanosine Monophosphate-dependent Protein Kinase I Promotes Adhesion of Primary Vascular Smooth Muscle Cells
    Weinmeister, Pascal
    Lukowski, Robert
    Linder, Stefan
    Traidl-Hoffmann, Claudia
    Hengst, Ludger
    Hofmann, Franz
    Feil, Robert
    MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (10) : 4434 - 4441
  • [4] Reactive Oxygen Species and RhoA Signaling in Vascular Smooth Muscle: Role in Chronic Hypoxia-Induced Pulmonary Hypertension
    Resta, Thomas C.
    Broughton, Brad R. S.
    Jernigan, Nikki L.
    MEMBRANE RECEPTORS, CHANNELS AND TRANSPORTERS IN PULMONARY CIRCULATION, 2010, 661 : 355 - 373
  • [5] Adenosine Monophosphate-Activated Protein Kinase Is Required for Pulmonary Artery Smooth Muscle Cell Survival and the Development of Hypoxic Pulmonary Hypertension
    Ibe, Joyce Christina F.
    Zhou, Qiyuan
    Chen, Tianji
    Tang, Haiyang
    Yuan, Jason X. -J.
    Raj, J. Usha
    Zhou, Guofei
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013, 49 (04) : 609 - 618
  • [6] Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: Role of cGMP-Dependent protein kinase
    Zhou, Weilin
    Dasgupta, Chiranjib
    Negash, Sewite
    Raj, J. Usha
    FASEB JOURNAL, 2007, 21 (06): : A1338 - A1339
  • [7] Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase
    Zhou, Weilin
    Dasgupta, Chiranjib
    Negash, Sewite
    Raj, J. Usha
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2007, 292 (06) : L1459 - L1466
  • [8] Generation of reactive oxygen species (ROS) in fetal pulmonary artery (PA) and vein (PV) smooth muscle (SMQ during hypoxia
    Sander, F
    Gan, YS
    Raj, U
    FASEB JOURNAL, 2004, 18 (04): : A714 - A714
  • [9] Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase and myocardin
    Zhou, Weilin
    Negash, Sewite
    Liu, Jie
    Raj, J. Usha
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 296 (05) : L780 - L789
  • [10] Akt-Dependent Vacuolar Protein Sorting 34 Activation Promotes Pulmonary Vascular Smooth Muscle Cell Proliferation and Survival in Pulmonary Hypertension
    Shen, Yuanjun
    Goncharov, Dmitry
    Jiang, Lifeng
    Lin, Derek
    Avolio, Theodore
    Okorie, Evelyn
    Mora, Ana L.
    Saiyed, Aisha
    CIRCULATION, 2022, 146
123