Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer

被引：41

作者：

Liu, Wenbo ^{[1
,2
]}

Tan, Xiaobin ^{[1
]}

Shu, Luan ^{[1
]}

Sun, Hanyan ^{[2
]}

Song, Jie ^{[1
]}

Jin, Ping ^{[1
]}

Yu, Siming ^{[2
]}

Sun, Min ^{[2
]}

Jia, Xiaobin ^{[1
]}

机构：

[1] Jiangsu Prov Acad Chinese Med, Key Lab Delivery Syst Chinese Meteria Med, Nanjing 210028, Jiangsu, Peoples R China

[2] Anhui Univ, Dept Life Sci, Hefei 230039, Anhui, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 08期

关键词：

Nrf2; CSE; phase II detoxifying enzymes; ursolic acid; chemopreventive; PRUNELLA-VULGARIS L; METABOLIZING-ENZYMES; SIGNALING PATHWAY; DNA-DAMAGE; CHEMOPREVENTION; APOPTOSIS; FIBROBLASTS; TRITERPENES; GROWTH; NRF2;

D O I：

10.3390/molecules17089104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered the intracellular redox balance, and relieved the stimulation of external deleterious factors as well. UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway. Moreover, UA inhibited lung cancer development in the model established by A549 cells in nude mice in vivo. For the first time, our results indicate that UA could be developed as a potential lung cancer chemopreventive agent.

引用

页码：9104 / 9115

页数：12

共 24 条

[1] Cigarette Smoke Extract (CSE) Delays NOD2 Expression and Affects NOD2/RIPK2 Interactions in Intestinal Epithelial Cells [J].

Aldhous, Marian C. ;

Soo, Kimberley ;

Stark, Lesley A. ;

Ulanicka, Agata A. ;

Easterbrook, Jennifer E. ;

Dunlop, Malcolm G. ;

Satsangi, Jack .

PLOS ONE, 2011, 6 (09)

[2] Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1 [J].

Cabello, Christopher M. ;

Bair, Warner B., III ;

Bause, Alexandra S. ;

Wondrak, Georg T. .

BIOCHEMICAL PHARMACOLOGY, 2009, 78 (04) :344-354

[3] Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts [J].

Carnevali, S ;

Petruzzelli, S ;

Longoni, B ;

Vanacore, R ;

Barale, R ;

Cipollini, M ;

Scatena, F ;

Paggiaro, P ;

Celi, A ;

Giuntini, C .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 284 (06) :L955-L963

[4] Vitamin E Modulates Cigarette Smoke Extract-induced Cell Apoptosis in Mouse Embryonic Cells [J].

Chen, Zhao-Li ;

Tao, Jian ;

Yang, Jie ;

Yuan, Zhen-Li ;

Liu, Xing-Hua ;

Jin, Min ;

Shen, Zhi-Qiang ;

Wang, Lu ;

Li, Hai-Feng ;

Qiu, Zhi-Gang ;

Wang, Jing-Feng ;

Wang, Xin-Wei ;

Li, Jun-Wen .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2011, 7 (07) :927-936

[5] Cytotoxic triterpenes from the aerial roots of Ficus microcarpa [J].

Chiang, YM ;

Chang, JY ;

Kuo, CC ;

Chang, CY ;

Kuo, YH .

PHYTOCHEMISTRY, 2005, 66 (04) :495-501

[6]

Feng L, 2010, ASIAN PAC J CANCER P, V11, P1355

[7] Combination of Active Components Enhances the Efficacy of Prunella in Prevention and Treatment of Lung Cancer [J].

Feng, Liang ;

Jia, Xiao-Bin ;

Jiang, Jun ;

Zhu, Mao-Mao ;

Chen, Yan ;

Tan, Xiao-Bin ;

Shi, Feng .

MOLECULES, 2010, 15 (11) :7893-7906

[8] Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity [J].

Feng, Liang ;

Jia, Xiao-Bin ;

Shi, Feng ;

Chen, Yan .

MOLECULES, 2010, 15 (08) :5093-5103

[9] Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts [J].

Kim, HJ ;

Liu, XD ;

Kobayashi, T ;

Conner, H ;

Kohyama, T ;

Wen, FQ ;

Fang, QH ;

Abe, S ;

Bitterman, P ;

Rennard, SI .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2004, 31 (05) :483-490

[10] Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers [J].

Kwak, MK ;

Wakabayashi, N ;

Kensler, TW .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 555 (1-2) :133-148

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