Growth factor network disruption in prostate cancer progression

被引:15
作者
Ware, JL [1 ]
机构
[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pathol, Richmond, VA 23298 USA
关键词
prostate; growth factors; networks;
D O I
10.1023/A:1006114527274
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Prostate cancer progression is often accompanied by alterations of expression in one or more growth factor receptors and/or their ligands. This commentary examines the hypothesis that the disruption of the normal growth factor network itself is a critical event in prostate cancer progression. If such transition points are proven, there are significant ramifications.
引用
收藏
页码:443 / 447
页数:5
相关论文
共 42 条
[1]   AUTOCRINE REGULATION OF CELL-PROLIFERATION BY THE INSULIN-LIKE GROWTH-FACTOR (IGF) AND IGF BINDING PROTEIN-3 PROTEASE SYSTEM IN A HUMAN PROSTATE CARCINOMA CELL-LINE (PC-3) [J].
ANGELLOZNICOUD, P ;
BINOUX, M .
ENDOCRINOLOGY, 1995, 136 (12) :5485-5492
[2]   TUMORIGENICITY OF SV40 T-ANTIGEN IMMORTALIZED HUMAN PROSTATE EPITHELIAL-CELLS - ASSOCIATION WITH DECREASED EPIDERMAL GROWTH-FACTOR RECEPTOR (EGFR) EXPRESSION [J].
BAE, VL ;
JACKSONCOOK, CK ;
BROTHMAN, AR ;
MAYGARDEN, SJ ;
WARE, JL .
INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (05) :721-729
[3]  
Bae VL, 1998, PROSTATE, V34, P275, DOI 10.1002/(SICI)1097-0045(19980301)34:4<275::AID-PROS5>3.0.CO
[4]  
2-G
[5]   Secretion of insulin-like growth factors and their binding proteins by human normal and hyperplastic prostatic cells in primary culture [J].
Boudon, C ;
Rodier, G ;
Lechevallier, E ;
Mottet, N ;
Barenton, B ;
Sultan, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (02) :612-617
[6]   EXPRESSION OF MESSENGER-RNA FOR EPIDERMAL GROWTH-FACTOR, TRANSFORMING GROWTH-FACTOR-ALPHA AND THEIR RECEPTOR IN HUMAN PROSTATE TISSUE AND CELL-LINES [J].
CHING, KZ ;
RAMSEY, E ;
PETTIGREW, N ;
DCUNHA, R ;
JASON, M ;
DODD, JG .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1993, 126 (02) :151-158
[7]   INSULIN-LIKE GROWTH-FACTORS (IGFS), IGF RECEPTORS, AND IGF-BINDING PROTEINS IN PRIMARY CULTURES OF PROSTATE EPITHELIAL-CELLS [J].
COHEN, P ;
PEEHL, DM ;
LAMSON, G ;
ROSENFELD, RG .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (02) :401-407
[8]   Overexpression of an inhibitory insulin-like growth factor binding protein (IGFBP), IGFBP-4, delays onset of prostate tumor formation [J].
Damon, SE ;
Maddison, L ;
Ware, JL ;
Plymate, SR .
ENDOCRINOLOGY, 1998, 139 (08) :3456-3464
[9]  
Douglas T H, 1998, Semin Urol Oncol, V16, P35
[10]  
ELSON SD, 1984, J CLIN ENDOCR METAB, V48, P673