Calcium phosphate cements as drug delivery materials

被引：448
作者：
Ginebra, Maria-Pau [1 ,2 ]
Canal, Cristina [1 ,2 ]
Espanol, Montserrat [1 ,2 ]
Pastorino, David [1 ,2 ]
Montufar, Edgar B. [1 ,2 ,3 ]
机构：
[1] Tech Univ Catalonia UPC, Dept Mat Sci & Met Engn, Biomat Biomech & Tissue Engn Grp, Barcelona 08028, Spain
[2] Biomed Res Networking Ctr Bioengn Biomat & Nanome, Zaragoza 50118, Spain
[3] Inst Bioengn Catalonia, Barcelona 08028, Spain
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷 / 12期
关键词：
Biomaterial; Calcium phosphate cement; Ceramic matrix; Bioceramic; Hydroxyapatite; Bone regeneration; Protein; Growth factor; Ions; Antibiotic; ALPHA-TRICALCIUM PHOSPHATE; IN-VIVO BEHAVIOR; OSTEOCLASTIC BONE-RESORPTION; SETTING CARBONATED-APATITE; TIBIAL PLATEAU FRACTURES; LOCAL ANTIBIOTIC-THERAPY; MESENCHYMAL STEM-CELLS; MIXING SOLUTION VOLUME; HYDROXYAPATITE CEMENT; CONTROLLED-RELEASE;
D O I：
10.1016/j.addr.2012.01.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work to: a) provide an overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system, and b) identify the most significant achievements. The drugs or active principles associated to calcium phosphate cements are classified in three groups, i) low molecular weight drugs; ii) high molecular weight biomolecules; and iii) ions. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：1090 / 1110
页数：21
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