Cu-mediated enamide formation in the total synthesis of complex peptide natural products

被引：127

作者：

Kuranaga, Takefumi ^{[1
]}

Sesoko, Yusuke ^{[1
]}

Inoue, Masayuki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 04期

关键词：

NUCLEOSIDE ANTIBIOTIC MUREIDOMYCIN; PSEUDOMONAS-AERUGINOSA ACTIVITY; SPHEROPLAST FORMING ACTIVITY; WADSWORTH-EMMONS REACTION; BRIDGED NUCLEIC-ACID; DEHYDROAMINO ACIDS; AMINO-ACIDS; STEREOCHEMICAL ASSIGNMENT; CYCLOPEPTIDE ALKALOIDS; ETHYL (DIARYLPHOSPHONO)ACETATES;

D O I：

10.1039/c3np70103d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cu-mediated C(sp(2))-N bond formation has received intense interest recently, and has been applied to the total synthesis of a wide variety of structurally complex natural products. This review covers the synthetic assembly of peptide natural products in which Cu-mediated enamide formation is the key transformation. The total syntheses of cyclopeptide alkaloids, pacidamycin D, and yaku'amide A exemplify the versatility of the Cu-catalyzed cross-coupling reaction in comparison to other synthetic methods.

引用

页码：514 / 532

页数：19

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