The Electrochemistry of Liposomes

This review aims to summarize the current state of research concerning the interaction of electrodes with liposomes suspended in solutions. Main attention is given to the complex mechanism of adhesion and spreading of liposomes on mercury electrodes. That mechanism call be studied with the help of chronoamperometry, where each adhesion-spreading event appears as a capacitive Current spike. Integration of these spikes produces charge versus, time transients that can be modeled and simulated, revealing the details of the multi-step adhesion-spreading process. Whereas the number. A spikes per time mirrors the macro-kinetics, the analysis of the time behavior of each spike mirrors the micro-kinetics of cacti adhesion-spreading event. The reviewed studies show that this approach provides a new tool to study the properties of liposome membranes. The adhesion-spreading of liposomes on mercury electrodes has strong similarities to the process of vesicle fusion, which makes these Studies it biomimetic model allowing one to deduce the effects of foreign molecules in bilayer membranes.