Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate

被引:7
作者
Green, Whitney M. [1 ]
Hicks, Jessica L. [1 ]
De Marzo, Angela [1 ]
Illei, Peter P. B. [1 ]
Epstein, Jonathan I. [1 ,2 ,3 ]
机构
[1] Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD 21231 USA
[2] Johns Hopkins Univ Hosp, Dept Urol, Baltimore, MD 21231 USA
[3] Johns Hopkins Univ Hosp, Dept Oncol, Baltimore, MD 21231 USA
关键词
Prostate; Adenosis; TMPRSS2; ERG; Adenocarcinoma; ATYPICAL ADENOMATOUS HYPERPLASIA; INTRAEPITHELIAL NEOPLASIA; TRANSITION ZONE; HISTOLOGIC FEATURES; ERG REARRANGEMENT; NEEDLE-BIOPSY; CANCER; CARCINOMA; SPECIMENS; ADENOCARCINOMA;
D O I
10.1016/j.humpath.2013.02.019
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Adenosis (atypical adenomatous hyperplasia) is a benign lesion that morphologically mimics prostate adenocarcinoma, although the relationship between these 2 lesions is still debated. The TMPRSS2-ERG fusion is a common chromosomal rearrangement that occurs early in the development of invasive adenocarcinoma of the prostate and results in the expression of a truncated ERG protein. This fusion is present in 50% of adenocarcinomas and in 20% of high-grade prostate intraepithelial lesions. Until recently, fluorescent in situ hybridization was the only method available to detect these rearrangements. A specific anti-ERG antibody is now available for detecting ERG protein expression and serves as a useful marker for ERG rearrangements. Formalin-fixed, paraffin-embedded tissue sections of adenosis from cases of prostate biopsies (n = 30), transurethral resections of the prostate (n = 12), and radical prostatectomies (n = 3) were analyzed via immunohistochemistry for ERG. None (0%) of the foci of adenosis were positive for ERG protein expression. Of 40 cases of Gleason score 6 adenocarcinoma on a tissue microarray, 22 (55%) were positive for ERG protein. Of the positive cases, 14 (63.6%) were moderate in intensity, with the remaining 36.4% being weak. The lack of ERG expression in adenosis supports the notion that it is not a precursor lesion of adenocarcinoma. Moreover, it suggests that immunohistochemistry for ERG expression could be a useful tool to differentiate adenosis from adenocarcinoma. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:1895 / 1901
页数:7
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