In this paper, an unrelated parallel machine scheduling problem with job (product) and machine acceptance and renewable resource constraints was considered. The main idea of this research was to establish a production facility without (or with minimum) investment in machinery, equipment, and location. This problem can be applied to many real problems. The objective was to maximize the net profit; that is, the total revenue minus the total cost, including fixed costs of jobs, job transportation costs, renting costs of machines, renting cost of resources, and transportation costs of resources. A mixed-integer linear programming (MILP) model and several heuristics (greedy, GRASP, and simulated annealing) are presented to solve the problem.