Risk Factors for Early and Late Transmission of HIV via Breast-Feeding among Infants Born to HIV-Infected Women in a Randomized Clinical Trial in Botswana

被引：16

作者：

Shapiro, Roger L. ^{[1
,2
]}

Smeaton, Laura ^{[3
]}

Lockman, Shahin ^{[2
,4
]}

Thior, Ibou ^{[5
]}

Rossenkhan, Raabya ^{[5
]}

Wester, Carolyn ^{[5
]}

Stevens, Lisa ^{[5
]}

Moffat, Claire ^{[5
]}

Arimi, Peter ^{[5
]}

Ndase, Patrick ^{[5
]}

Asmelash, Aida ^{[5
]}

Leidner, Jean ^{[3
]}

Novitsky, Vladimir ^{[2
]}

Makhema, Joseph ^{[5
]}

Essex, Max ^{[2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Infect Dis Unit, Boston, MA 02115 USA

[5] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 03期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; LATE POSTNATAL TRANSMISSION; TO-CHILD TRANSMISSION; ZIDOVUDINE; MILK; PROPHYLAXIS; NEVIRAPINE; COHORT;

D O I：

10.1086/596034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Risk factors for mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) via breast-feeding were evaluated in a randomized trial. HIV-infected women and their infants received zidovudine as well as single-dose nevirapine or placebo. Infants were randomized to formula-feed (FF) or breast-feed (BF) in combination with zidovudine prophylaxis. Of 1116 at-risk infants, 6 (1.1%) in the FF group and 7 (1.3%) in the BF group were infected between birth and 1 month (P = .99). Maternal receipt of nevirapine did not predict early MTCT in the BF group (P = .45). Of 547 infants in the BF group at risk for late MTCT, 24 (4.4%) were infected. Maternal HIV-1 RNA levels in plasma (P < .001) and breast milk (P < .001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis.

引用

页码：414 / 418

页数：5

共 25 条

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