Risk Factors for Early and Late Transmission of HIV via Breast-Feeding among Infants Born to HIV-Infected Women in a Randomized Clinical Trial in Botswana

被引：16
|
作者：
Shapiro, Roger L. [1 ,2 ]
Smeaton, Laura [3 ]
Lockman, Shahin [2 ,4 ]
Thior, Ibou [5 ]
Rossenkhan, Raabya [5 ]
Wester, Carolyn [5 ]
Stevens, Lisa [5 ]
Moffat, Claire [5 ]
Arimi, Peter [5 ]
Ndase, Patrick [5 ]
Asmelash, Aida [5 ]
Leidner, Jean [3 ]
Novitsky, Vladimir [2 ]
Makhema, Joseph [5 ]
Essex, Max [2 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Infect Dis Unit, Boston, MA 02115 USA
[5] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana
来源：
JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 03期
关键词：
IMMUNODEFICIENCY-VIRUS TYPE-1; LATE POSTNATAL TRANSMISSION; TO-CHILD TRANSMISSION; ZIDOVUDINE; MILK; PROPHYLAXIS; NEVIRAPINE; COHORT;
D O I：
10.1086/596034
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Risk factors for mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) via breast-feeding were evaluated in a randomized trial. HIV-infected women and their infants received zidovudine as well as single-dose nevirapine or placebo. Infants were randomized to formula-feed (FF) or breast-feed (BF) in combination with zidovudine prophylaxis. Of 1116 at-risk infants, 6 (1.1%) in the FF group and 7 (1.3%) in the BF group were infected between birth and 1 month (P = .99). Maternal receipt of nevirapine did not predict early MTCT in the BF group (P = .45). Of 547 infants in the BF group at risk for late MTCT, 24 (4.4%) were infected. Maternal HIV-1 RNA levels in plasma (P < .001) and breast milk (P < .001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis.
引用
收藏
页码：414 / 418
页数：5
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