Long Non-Coding RNA in Cancer

被引：325
作者：
Hauptman, Nina [1 ]
Glavac, Damjan [1 ]
机构：
[1] Univ Ljubljana, Inst Pathol, Dept Mol Genet, SI-1000 Ljubljana, Slovenia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 03期
关键词：
long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA; TUMOR-SUPPRESSOR GENE; PROTEIN-CODING RNA; UP-REGULATION; HEPATOCELLULAR-CARCINOMA; EXPRESSION; HOTAIR; GROWTH; LOCUS; TRANSCRIPTION; APOPTOSIS;
D O I：
10.3390/ijms14034655
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.
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页码：4655 / 4669
页数：15
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