Long Non-Coding RNA in Cancer

被引：325
作者：
Hauptman, Nina [1 ]
Glavac, Damjan [1 ]
机构：
[1] Univ Ljubljana, Inst Pathol, Dept Mol Genet, SI-1000 Ljubljana, Slovenia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 03期
关键词：
long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA; TUMOR-SUPPRESSOR GENE; PROTEIN-CODING RNA; UP-REGULATION; HEPATOCELLULAR-CARCINOMA; EXPRESSION; HOTAIR; GROWTH; LOCUS; TRANSCRIPTION; APOPTOSIS;
D O I：
10.3390/ijms14034655
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.
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页码：4655 / 4669
页数：15
相关论文
共 105 条
  • [1] lncRNAdb: a reference database for long noncoding RNAs
    Amaral, Paulo P.
    Clark, Michael B.
    Gascoigne, Dennis K.
    Dinger, Marcel E.
    Mattick, John S.
    [J]. NUCLEIC ACIDS RESEARCH, 2011, 39 : D146 - D151
  • [2] [Anonymous], 2007, NUCL RECEPT SIGNAL, DOI DOI 10.1621/NRS.05006
  • [3] Association of IGF2 and H19 imprinting with choriocarcinoma development
    Arima, T
    Matsuda, T
    Takagi, N
    Wake, N
    [J]. CANCER GENETICS AND CYTOGENETICS, 1997, 93 (01) : 39 - 47
  • [4] Long noncoding RNAs are rarely translated in two human cell lines
    Banfai, Balazs
    Jia, Hui
    Khatun, Jainab
    Wood, Emily
    Risk, Brian
    Gundling, William E., Jr.
    Kundaje, Anshul
    Gunawardena, Harsha P.
    Yu, Yanbao
    Xie, Ling
    Krajewski, Krzysztof
    Strahl, Brian D.
    Chen, Xian
    Bickel, Peter
    Giddings, Morgan C.
    Brown, James B.
    Lipovich, Leonard
    [J]. GENOME RESEARCH, 2012, 22 (09) : 1646 - 1657
  • [5] The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis
    Barsyte-Lovejoy, Dalia
    Lau, Suzanne K.
    Boutros, Paul C.
    Khosravi, Fereshteh
    Jurisica, Igor
    Andrulis, Irene L.
    Tsao, Ming S.
    Penn, Linda Z.
    [J]. CANCER RESEARCH, 2006, 66 (10) : 5330 - 5337
  • [6] MEG3 imprinted gene contribution in tumorigenesis
    Benetatos, Leonidas
    Vartholomatos, George
    Hatzimichael, Eleftheria
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (04) : 773 - 779
  • [7] H19 mRNA-like noncoding RNA promotes breast cancer cell proliferation through positive control by E2F1
    Berteaux, N
    Lottin, V
    Monté, D
    Pinte, S
    Quatannens, B
    Coll, J
    Hondermarck, H
    Curgy, JJ
    Dugimont, T
    Adriaenssens, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (33) : 29625 - 29636
  • [8] Birney E., 2007, BIOESSAYS, V32, P599
  • [9] Chen W, 1997, J PATHOL, V183, P345, DOI 10.1002/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO
  • [10] 2-8
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