T-bet: a bridge between innate and adaptive immunity

被引：386

作者：

Lazarevic, Vanja ^{[1
]}

Glimcher, Laurie H. ^{[2
]}

Lord, Graham M. ^{[3
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

[2] Weill Cornell Med Coll, New York, NY 10065 USA

[3] Kings Coll London, Dept Expt Immunobiol, London SE1 9RT, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 11期

基金：

英国医学研究理事会; 英国惠康基金; 美国国家卫生研究院;

关键词：

CHRONIC VIRAL-INFECTION; IFN-GAMMA PRODUCTION; TRANSCRIPTION FACTOR EOMESODERMIN; TH1; CELL-DIFFERENTIATION; PATHOGENIC T(H)17 CELLS; V-ALPHA-14I NKT CELLS; GENE-EXPRESSION; LYMPHOID-CELLS; INTERFERON-GAMMA; DENDRITIC CELLS;

D O I：

10.1038/nri3536

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet.

引用

页码：777 / 789

页数：13

共 107 条

[41] The Development of Airway Hyperreactivity in T-bet-Deficient Mice Requires CD1d-Restricted NKT Cells [J].

Kim, Hye Young ;

Pichavant, Muriel ;

Matangkasombut, Ponpan ;

Koh, Youngil I. ;

Savage, Paul B. ;

DeKruyff, Rosemarie H. ;

Umetsu, Dale T. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :3252-3261

[42] A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells [J].

Klose, Christoph S. N. ;

Kiss, Elina A. ;

Schwierzeck, Vera ;

Ebert, Karolina ;

Hoyler, Thomas ;

d'Hargues, Yannick ;

Goeppert, Nathalie ;

Croxford, Andrew L. ;

Waisman, Ari ;

Tanriver, Yakup ;

Diefenbach, Andreas .

NATURE, 2013, 494 (7436) :261-265

[43] T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 [J].

Koch, Meghan A. ;

Thomas, Kerri R. ;

Perdue, Nikole R. ;

Smigiel, Kate S. ;

Srivastava, Shivani ;

Campbell, Daniel J. .

IMMUNITY, 2012, 37 (03) :501-510

[44] The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation [J].

Koch, Meghan A. ;

Tucker-Heard, Glady's ;

Perdue, Nikole R. ;

Killebrew, Justin R. ;

Urdahl, Kevin B. ;

Campbell, Daniel J. .

NATURE IMMUNOLOGY, 2009, 10 (06) :595-U57

[45] T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt [J].

Lazarevic, Vanja ;

Chen, Xi ;

Shim, Jae-Hyuck ;

Hwang, Eun-Sook ;

Jang, Eunjung ;

Bolm, Alexandra N. ;

Oukka, Mohamed ;

Kuchroo, Vijay K. ;

Glimcher, Laurie H. .

NATURE IMMUNOLOGY, 2011, 12 (01) :96-U124

[46] Induction and molecular signature of pathogenic TH17 cells [J].

Lee, Youjin ;

Awasthi, Amit ;

Yosef, Nir ;

Quintana, Francisco J. ;

Xiao, Sheng ;

Peters, Anneli ;

Wu, Chuan ;

Kleinewietfeld, Markus ;

Kunder, Sharon ;

Hafler, David A. ;

Sobel, Raymond A. ;

Regev, Aviv ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2012, 13 (10) :991-999

[47] Late Developmental Plasticity in the T Helper 17 Lineage [J].

Lee, Yun Kyung ;

Turner, Henrietta ;

Maynard, Craig L. ;

Oliver, James R. ;

Chen, Dongquan ;

Elson, Charles O. ;

Weaver, Casey T. .

IMMUNITY, 2009, 30 (01) :92-107

[48] Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages [J].

Liao, Wei ;

Lin, Jian-Xin ;

Wang, Lu ;

Li, Peng ;

Leonard, Warren J. .

NATURE IMMUNOLOGY, 2011, 12 (06) :551-U247

[49] T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells [J].

Lighvani, AA ;

Frucht, DM ;

Jankovic, D ;

Yamane, H ;

Aliberti, J ;

Hissong, BD ;

Nguyen, BV ;

Gadina, M ;

Sher, A ;

Paul, WE ;

O'Shea, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :15137-15142

[50] T-bet is required for optimal proinflammatory CD4+ T-cell trafficking [J].

Lord, GM ;

Rao, RM ;

Choe, H ;

Sullivan, BM ;

Lichtman, AH ;

Luscinskas, FW ;

Glimcher, LH .

BLOOD, 2005, 106 (10) :3432-3439

← 1 2 3 4 5 6 7 8 9 10 →