T-bet: a bridge between innate and adaptive immunity

被引：373
作者：
Lazarevic, Vanja [1 ]
Glimcher, Laurie H. [2 ]
Lord, Graham M. [3 ]
机构：
[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA
[2] Weill Cornell Med Coll, New York, NY 10065 USA
[3] Kings Coll London, Dept Expt Immunobiol, London SE1 9RT, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 11期
基金：
英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;
关键词：
CHRONIC VIRAL-INFECTION; IFN-GAMMA PRODUCTION; TRANSCRIPTION FACTOR EOMESODERMIN; TH1; CELL-DIFFERENTIATION; PATHOGENIC T(H)17 CELLS; V-ALPHA-14I NKT CELLS; GENE-EXPRESSION; LYMPHOID-CELLS; INTERFERON-GAMMA; DENDRITIC CELLS;
D O I：
10.1038/nri3536
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet.
引用
收藏
页码：777 / 789
页数：13
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