Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19

被引：5

作者：

Kanekura, Takuro ^{[1
]}

Kawahara, Koichi ^{[2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dermatol, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan

[2] Osaka Inst Technol, Dept Biomed Engn, Lab Funct Foods, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 99卷

关键词：

SARS-CoV-2; COVID-19; Adsorptive granulocyte and monocyte apheresis; MYELOID LINEAGE LEUKOCYTES; PSORIATIC-ARTHRITIS; NEUTROPHILS; DEPLETION;

D O I：

10.1016/j.ijid.2020.07.025

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The overproduction of proinflammatory cytokines and subsequent thromboembolism are major problems of coronavirus disease 2019 (COVID-19). Adsorptive granulocyte and monocyte apheresis (GMA), used for ulcerative colitis, is an extracorporeal therapy designed to remove activated myeloid lineage cells. Previous studies have demonstrated that GMA decreases proinflammatory cytokines and neutrophil-platelet aggregates. The effect of GMA on COVID-19 in a patient with ulcerative colitis was recently reported. The modes of action of GMA together with the findings of this case report indicate that GMA could be a relevant treatment option for COVID-19. (c) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：1 / 2

页数：2

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