Bacterial chitinases and chitin-binding proteins as virulence factors

被引：135

作者：

Frederiksen, Rikki F. ^{[1
]}

Paspaliari, Dafni K. ^{[1
]}

Larsen, Tanja ^{[1
]}

Storgaard, Birgit G. ^{[1
,2
]}

Larsen, Marianne H. ^{[1
]}

Ingmer, Hanne ^{[1
]}

Palcic, Monica M. ^{[2
]}

Leisner, Jorgen J. ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth Sci, Dept Vet Dis Biol, DK-1870 Frederiksberg C, Denmark

[2] Carlsberg Lab, DK-1799 Copenhagen V, Denmark

来源：

MICROBIOLOGY-SGM | 2013年 / 159卷

关键词：

ENTERICA SEROVAR TYPHIMURIUM; BACILLUS-CIRCULANS WL-12; ENTEROCOCCUS-FAECALIS V583; PSEUDOMONAS-AERUGINOSA; FRANCISELLA-TULARENSIS; GENE-EXPRESSION; LEGIONELLA-PNEUMOPHILA; SERRATIA-MARCESCENS; EPITHELIAL-CELLS; REPEATING UNIT;

D O I：

10.1099/mic.0.051839-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

引用

页码：833 / 847

页数：15

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