Effects of Electric Field Stress on a β-Amyloid Peptide

被引：82

作者：

Toschi, Francesca ^{[1
]}

Lugli, Francesca ^{[1
]}

Biscarini, Fabio ^{[2
]}

Zerbetto, Francesco ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] CNR, ISMN, I-40126 Bologna, Italy

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2009年 / 113卷 / 01期

关键词：

INSULIN CHAIN-B; MOLECULAR-DYNAMICS; CONFORMATION; EXPOSURE; PHONES; BRAIN;

D O I：

10.1021/jp807896g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interaction of beta-amyloid (A beta) peptides with externally applied electric fields (EF) of varying strengths was investigated by means of molecular dynamics (MD) simulations. The results suggest that the EF favors the switch of A beta-peptides from helical to beta-sheet conformation, and a mechanism is tentatively proposed. Switching off the field does not restore the original conformation.

引用

页码：369 / 376

页数：8

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