Classical Reagents: New Surprises in Palladium-Catalyzed C-C Coupling Reactions

被引：30
作者：
Lindhardt, Anders T. [1 ,2 ]
Skrydstrup, Troels [1 ,2 ]
机构：
[1] Aarhus Univ, Dept Chem, Ctr Insoluble Prot Struct inSPIN, DK-8000 Aarhus, Denmark
[2] Aarhus Univ, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus, Denmark
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 29期
基金：
新加坡国家研究基金会;
关键词：
alkynes; hydride elimination; C-C coupling reactions; hydropalladation; palladium;
D O I：
10.1002/chem.200800608
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
From investigations on a relatively simple concept to identify conditions for promoting Mizoroki-Heck reactions with vinyl tosylates and phosphates, two serendipitous discoveries were made concerning new properties of palladium as a catalyst. In the first case, beta-hydride eliminations well known for alkyl metal complexes were found to be equally feasible with alkenyl metal compounds. And secondly, conditions were found for promoting intermolecular ene-yne couplings via a Pd-II-H intermediate. This coupling reactions represents an atom economical Mizoroki-Heck type reaction.
引用
收藏
页码：8756 / 8766
页数：11
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