Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan

被引：197

作者：

Ha, Sungji ^{[1
,2
]}

Sohn, In-Jung ^{[1
,2
,3
]}

Kim, Namwook ^{[1
,2
,3
]}

Sim, Hyeon Jeong ^{[1
,2
]}

Cheon, Keun-Ah ^{[1
,2
,3
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Psychiat, Inst Behav Sci Med, Seoul 03722, South Korea

[2] Yonsei Univ, Coll Med, Yonsei Autism Lab, Seoul 03722, South Korea

[3] Yonsei Univ, Coll Med, Severance Childrens Hosp, Div Child & Adolescent Psychiat, Seoul 03722, South Korea

来源：

EXPERIMENTAL NEUROBIOLOGY | 2015年 / 24卷 / 04期

关键词：

Autism spectrum disorder (ASD); Neuroimaging; Magnetic resonance image (MRI); Functional MRI (fMRI); Diffusion tensor image (DTI); REPETITIVE BEHAVIORS; SURFACE-AREA; STEREOTYPED BEHAVIORS; CORTICAL THICKNESS; MATTER VOLUME; CHILDREN; IMITATION; NETWORK; FMRI; CORTEX;

D O I：

10.5607/en.2015.24.4.273

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by impaired social communication and restricted and repetitive behaviors (RRBs). Over the past decade, neuroimaging studies have provided considerable insights underlying neurobiological mechanisms of ASD. In this review, we introduce recent findings from brain imaging studies to characterize the brains of ASD across the human lifespan. Results of structural Magnetic Resonance Imaging (MRI) studies dealing with total brain volume, regional brain structure and cortical area are summarized. Using task-based functional MRI (fMRI), many studies have shown dysfunctional activation in critical areas of social communication and RRBs. We also describe several data to show abnormal connectivity in the ASD brains. Finally, we suggest the possible strategies to study ASD brains in the future.

引用

页码：273 / 284

页数：12

共 93 条

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