Evaluation of Antihypertensive and Antihyperlipidemic Effects of Bamboo Shoot Angiotensin Converting Enzyme Inhibitory Peptide in Vivo

Cardiovascular protective functions of bamboo shoot angiotensin. Converting enzyme (ACE) inhibitory :peptide (BSP) from bamboo shoot Were evaluated, including antihypertensive effect on spontaneously hypertensive rats (SHRs) an antihyperlipidemic effect on :high-fat-diet-induced rats. Thirty day antihypertensive effects of BSP on SHRs were assayed. Asp. Tyr [10 mg/day kg body weight (BW)] and BSP (50 mg/day kg BW) significantly reduced ACE activity in lung at the same level (p < 0.05), while BSP (50 mg/day kg BW) reduced systolic blood pressure (SBP) more effectively for its phenolic compounds, such as ferulic acid and p-coumaric. acid, which when combined with ACE inhibitor exert a synergistic effect BSP could significantly reduce SBP, improve oxidant stress Status (GSH-Px, SOD, TAC and MDA), and increase NO level in serum and NOS activity in kidney. BSP decreased total cholesterol.(TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-c) content and MDA level of hyperlipidemic rats, which might contribute to the ACE inhibitory capacity of Asp Tyr and the fatty acid synthase inhibitory activity of phenolic compounds.