Alternative splicing and genome complexity

被引:369
作者
Brett, D
Pospisil, H
Valcárcel, J
Reich, J
Bork, P
机构
[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
[2] European Mol Biol Lab, D-69012 Heidelberg, Germany
关键词
D O I
10.1038/ng803
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.
引用
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页码:29 / 30
页数:2
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