A rush to judgment on Th17

被引:139
作者
Steinman, Lawrence [1 ,2 ]
机构
[1] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[2] Stanford Univ, Interdept Program Immunol, Beckman Ctr Mol Med, Stanford, CA 94305 USA
关键词
D O I
10.1084/jem.20072066
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity. Thus, the role of Th17 cytokines as the central mediators of pathological tissue damage seems to require clarification.
引用
收藏
页码:1517 / 1522
页数:6
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[31]   Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis [J].
Lock, C ;
Hermans, G ;
Pedotti, R ;
Brendolan, A ;
Schadt, E ;
Garren, H ;
Langer-Gould, A ;
Strober, S ;
Cannella, B ;
Allard, J ;
Klonowski, P ;
Austin, A ;
Lad, N ;
Kaminski, N ;
Galli, SJ ;
Oksenberg, JR ;
Raine, CS ;
Heller, R ;
Steinman, L .
NATURE MEDICINE, 2002, 8 (05) :500-508
[32]   Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes [J].
Lovett-Racke, AE ;
Rocchini, AE ;
Choy, J ;
Northrop, SC ;
Hussain, RZ ;
Ratts, RB ;
Sikder, D ;
Racke, MK .
IMMUNITY, 2004, 21 (05) :719-731
[33]   Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category [J].
Luger, Dror ;
Silver, Phyllis B. ;
Tang, Jun ;
Cua, Daniel ;
Chen, Zoe ;
Iwakura, Yoichiro ;
Bowman, Edward P. ;
Sgambellone, Nicole M. ;
Chan, Chi-Chao ;
Caspi, Rachel R. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (04) :799-810
[34]   Glia-dependent TGF-β signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis [J].
Luo, Jian ;
Ho, Peggy P. ;
Buckwalter, Marion S. ;
Hsu, Tiffany ;
Lee, Lowen Y. ;
Zhang, Hui ;
Kim, Dae-Kee ;
Kim, Seong-Jin ;
Gambhir, Sanjiv S. ;
Steinman, Lawrence ;
Wyss-Coray, Tony .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (11) :3306-3315
[35]   The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt [J].
Manel, Nicolas ;
Unutmaz, Derya ;
Littman, Dan R. .
NATURE IMMUNOLOGY, 2008, 9 (06) :641-649
[36]  
MING OL, 2007, IMMUNITY, V26, P579
[37]   IL-17 receptor signaling influences virus-induced corneal inflammation [J].
Molesworth-Kenyon, Sara J. ;
Yin, Rong ;
Oakes, John E. ;
Lausch, Robert N. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 83 (02) :401-408
[38]   TREATMENT OF MULTIPLE-SCLEROSIS WITH GAMMA-INTERFERON - EXACERBATIONS ASSOCIATED WITH ACTIVATION OF THE IMMUNE-SYSTEM [J].
PANITCH, HS ;
HIRSCH, RL ;
SCHINDLER, J ;
JOHNSON, KP .
NEUROLOGY, 1987, 37 (07) :1097-1102
[39]   Systemic lupus erythematosus: all roads lead to type I interferons [J].
Pascual, Virginia ;
Farkas, Lorant ;
Banchereau, Jacques .
CURRENT OPINION IN IMMUNOLOGY, 2006, 18 (06) :676-682
[40]   Interleukin-17 is a negative regulator of established allergic asthma [J].
Schnyder-Candrian, Silvia ;
Togbe, Dieudonnee ;
Couillin, Isabelle ;
Mercier, Isabelle ;
Brombacher, Frank ;
Quesniaux, Valerie ;
Fossiez, Francois ;
Ryffel, Bernhard ;
Schnyder, Bruno .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2715-2725