A rush to judgment on Th17

被引：139

作者：

Steinman, Lawrence ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Interdept Program Immunol, Beckman Ctr Mol Med, Stanford, CA 94305 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 07期

关键词：

D O I：

10.1084/jem.20072066

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity. Thus, the role of Th17 cytokines as the central mediators of pathological tissue damage seems to require clarification.

引用

页码：1517 / 1522

页数：6

共 50 条

[1] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].

Acosta-Rodriguez, Eva V. ;

Napolitani, Giorgio ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2007, 8 (09) :942-949

[2]

[Anonymous], CANON

[3]

Arnason BGW, 1999, ANNU REV MED, V50, P291

[4] Type 1 interferons cool the inflamed brain [J].

Axtell, Robert C. ;

Steinman, Lawrence .

IMMUNITY, 2008, 28 (05) :600-602

[5] Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis [J].

Bettelli, E ;

Sullivan, B ;

Szabo, SJ ;

Sobel, RA ;

Glimcher, H ;

Kuchroo, VK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (01) :79-87

[6] TH-17 cells in the circle of immunity and autoimmunity [J].

Bettelli, Estelle ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2007, 8 (04) :345-350

[7]

BILLIAU A, 1988, J IMMUNOL, V140, P1506

[8]

CASPI RR, 1994, J IMMUNOL, V152, P890

[9] The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease [J].

Chabas, D ;

Baranzini, SE ;

Mitchell, D ;

Bernard, CCA ;

Rittling, SR ;

Denhardt, DT ;

Sobel, RA ;

Lock, C ;

Karpuj, M ;

Pedotti, R ;

Heller, R ;

Oksenberg, JR ;

Steinman, L .

SCIENCE, 2001, 294 (5547) :1731-1735

[10] Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis [J].

Chitnis, T ;

Najafian, N ;

Benou, C ;

Salama, AD ;

Grusby, MJ ;

Sayegh, MH ;

Khoury, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (05) :739-747

← 1 2 3 4 5 →