Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

被引：58

作者：

Dubiel, Wolfgang ^{[1
]}

Dubiel, Dawadschargal ^{[2
]}

Wolf, Dieter A. ^{[1
,3
]}

Naumann, Michael ^{[2
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, Xiangan South Rd, Xiamen 361102, Peoples R China

[2] Otto Von Guericke Univ, Inst Expt Internal Med, Med Fac, Leipziger Str 44, D-39120 Magdeburg, Germany

[3] Sanford Burnham Prebys Med Discovery Inst, Tumor Initiat & Maintenance Program, 10901 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2018年 / 43卷 / 02期

基金：

美国国家卫生研究院;

关键词：

RHO GTPASES; DEPENDENT PROTEOLYSIS; COP9; SIGNALOSOME; SUBSTRATE; ACTIVATION; COMPLEXES; PATHWAY; SCF; DEGRADATION; INSIGHTS;

D O I：

10.1016/j.tibs.2017.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Specificity of the ubiquitin proteasome system is controlled by ubiquitin E3 ligases, including their major representatives, the multisubunit cullin-RING ubiquitin (Ub) ligases (CRLs). More than 200 different CRLs are divided into seven families according to their cullin scaffolding proteins (CUL1-7) around which they are assembled. Research over two decades has revealed that different CRL families are specialized to fulfill specific cellular functions. Whereas many CUL1-based CRLs (CRL1s) ubiquitylate cell cycle regulators, CRL4 complexes often associate with chromatin to control DNA metabolism. Based on studies about differentiation programs of mesenchymal stem cells (MSCs), including myogenesis, neurogenesis, chondrogenesis, osteogenesis and adipogenesis, we propose here that CRL3 complexes evolved to fulfill a pivotal role in mammalian cell differentiation.

引用

页码：95 / 107

页数：13

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