Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice

被引：30

作者：

Takanashi, Seiji ^{[2
]}

Hara, Kazuo ^{[2
]}

Aoki, Kaoru ^{[2
]}

Usui, Yuki ^{[3
]}

Shimizu, Masayuki ^{[2
]}

Haniu, Hisao ^{[2
]}

Ogihara, Nobuhide ^{[2
]}

Ishigaki, Norio ^{[2
]}

Nakamura, Koichi ^{[2
]}

Okamoto, Masanori ^{[2
]}

Kobayashi, Shinsuke ^{[2
]}

Kato, Hiroyuki ^{[2
]}

Sano, Kenji ^{[4
]}

Nishimura, Naoyuki ^{[5
]}

Tsutsumi, Hideki ^{[6
]}

Machida, Kazuhiko ^{[6
]}

Saito, Naoto ^{[1
]}

机构：

[1] Shinshu Univ, Dept Appl Phys Therapy, Sch Hlth Sci, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Orthopaed Surg, Matsumoto, Nagano 3908621, Japan

[3] Shinshu Univ, Sch Engn, Dept Res Ctr Exot Nanocarbons, Nagano 3808553, Japan

[4] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano 3908621, Japan

[5] Nakashima Med Co Ltd, R&D Ctr, Kita Ku, Okayama 7011221, Japan

[6] Cent Inst Expt Anim, Testing Dept, Kawasaki Ku, Kawasaki, Kanagawa 2100821, Japan

来源：

SCIENTIFIC REPORTS | 2012年 / 2卷

基金：

日本科学技术振兴机构;

关键词：

IN-VITRO; ANIMAL-MODELS; TOXICITY; BATTERY; ASBESTOS; FIBERS; ARRAYS; ISSUES;

D O I：

10.1038/srep00498

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxicity evaluations are required. Among these evaluations, carcinogenicity should be examined with the highest priority; however, no report using transgenic mice to evaluate the carcinogenicity of CNTs has been published to date. Here, we performed a carcinogenicity test by implanting multi-walled CNTs (MWCNTs) into the subcutaneous tissue of rasH2 mice, using the carbon black present in black tattoo ink as a reference material for safety. The rasH2 mice did not develop neoplasms after being injected with MWCNTs; instead, MWCNTs showed lower carcinogenicity than carbon black. Such evaluations should facilitate the clinical application and development of CNTs for use in important medical fields.

引用

页数：7

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