Bleeding complications during anticoagulant treatment in patients with cancer

被引：69
作者：
Kamphuisen, Pieter W. [1 ]
Beyer-Westendorf, Jan [2 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Vasc Med, Groningen, Netherlands
[2] Tech Univ Dresden, Div Vasc Med, Dept Med, D-01062 Dresden, Germany
来源：
THROMBOSIS RESEARCH | 2014年 / 133卷
关键词：
Anticoagulation; Bleeding; Cancer; Venous thromboembolism; MOLECULAR-WEIGHT HEPARIN; VENOUS THROMBOEMBOLISM PROPHYLAXIS; MEDICAL PATIENTS; CLINICAL-ONCOLOGY; AMERICAN-SOCIETY; UNFRACTIONATED HEPARIN; RECEIVING CHEMOTHERAPY; SECONDARY PREVENTION; ADVANCED MALIGNANCY; PANCREATIC-CANCER;
D O I：
10.1016/S0049-3848(14)50009-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with cancer have an increased risk of bleeding complications, of which some are fatal. This risk is influenced by chemotherapy, cancer type and stage, thrombocytopenia, renal function, and previous bleeding. Since many cancer patients receive anticoagulant treatment for prophylaxis or treatment of venous thromboembolism (VTE), bleeding complications are a challenge in clinical practice. This review article focuses on the overall bleeding risk of cancer patients and the risk of major and clinically relevant bleeding associated with anticoagulant treatment, such as vitamin K antagonists, LMWH and the direct oral anticoagulants. It also describes strategies for individual risk assessments. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S49 / S55
页数：7
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