Vitamin D receptor activation: cardiovascular and renal implications

被引：18

作者：

Nigwekar, Sagar U. ^{[1
]}

Thadhani, Ravi ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02114 USA

来源：

KIDNEY INTERNATIONAL SUPPLEMENTS | 2013年 / 3卷 / 05期

关键词：

chronic kidney disease; end-stage renal disease; hypertension; left ventricular hypertrophy; vitamin D; vitamin D-binding protein; CHRONIC KIDNEY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; 1,25-DIHYDROXYVITAMIN D-3; VASCULAR CALCIFICATION; HEART-FAILURE; D DEFICIENCY; HEMODIALYSIS; HYPERTROPHY; ASSOCIATION; PARICALCITOL;

D O I：

10.1038/kisup.2013.89

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of vitamin D receptor activation on cardiovascular diseases, especially hypertension and cardiac dysfunction, are areas of active investigation. This article reviews the current state of knowledge about vitamin D receptor activation with respect to blood pressure, heart, and vascular health, as well as to chronic kidney disease and end-stage renal disease. Potential biological mechanisms, the role of vitamin D-binding protein, and data from observational and randomized controlled trials on this topic are summarized.

引用

页码：427 / 430

页数：4

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