Vitamin D receptor activation: cardiovascular and renal implications

被引：18

作者：

Nigwekar, Sagar U. ^{[1
]}

Thadhani, Ravi ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02114 USA

来源：

KIDNEY INTERNATIONAL SUPPLEMENTS | 2013年 / 3卷 / 05期

关键词：

chronic kidney disease; end-stage renal disease; hypertension; left ventricular hypertrophy; vitamin D; vitamin D-binding protein; CHRONIC KIDNEY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; 1,25-DIHYDROXYVITAMIN D-3; VASCULAR CALCIFICATION; HEART-FAILURE; D DEFICIENCY; HEMODIALYSIS; HYPERTROPHY; ASSOCIATION; PARICALCITOL;

D O I：

10.1038/kisup.2013.89

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of vitamin D receptor activation on cardiovascular diseases, especially hypertension and cardiac dysfunction, are areas of active investigation. This article reviews the current state of knowledge about vitamin D receptor activation with respect to blood pressure, heart, and vascular health, as well as to chronic kidney disease and end-stage renal disease. Potential biological mechanisms, the role of vitamin D-binding protein, and data from observational and randomized controlled trials on this topic are summarized.

引用

页码：427 / 430

页数：4

共 31 条

[1] Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction [J].

Bae, Soochan ;

Singh, Sylvia S. ;

Yu, Hyeon ;

Lee, Ji Yoo ;

Cho, Byung Ryul ;

Kang, Peter M. .

JOURNAL OF APPLIED PHYSIOLOGY, 2013, 114 (08) :979-987

[2] Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients [J].

Bhan, Ishir ;

Powe, Camille E. ;

Berg, Anders H. ;

Ankers, Elizabeth ;

Wenger, Julia B. ;

Karumanchi, S. Ananth ;

Thadhani, Ravi I. .

KIDNEY INTERNATIONAL, 2012, 82 (01) :84-89

[3] Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals [J].

Bodyak, Natalya ;

Ayus, Juan Carlos ;

Achinger, Steven ;

Shivalingappa, Venkatesha ;

Ke, Qingen ;

Chen, Yee-Shiuan ;

Rigor, Debra L. ;

Stillman, Isaac ;

Tamez, Hector ;

Kroeger, Paul E. ;

Wu-Wong, Ruth R. ;

Karumanchi, S. Ananth ;

Thadhani, Ravi ;

Kang, Peter M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) :16810-16815

[4] Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis [J].

Burgaz, Ann ;

Orsini, Nicola ;

Larsson, Susanna C. ;

Wolk, Alicja .

JOURNAL OF HYPERTENSION, 2011, 29 (04) :636-645

[5] Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy [J].

Chen, Songcang ;

Law, Christopher S. ;

Grigsby, Christopher L. ;

Olsen, Keith ;

Hong, Ting-Ting ;

Zhang, Yan ;

Yeghiazarians, Yerem ;

Gardner, David G. .

CIRCULATION, 2011, 124 (17) :1838-U159

[6]

de Borst MH, 2013, J AM SOC NEPHROL

[7] Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial [J].

de Zeeuw, Dick ;

Agarwal, Rajiv ;

Amdahl, Michael ;

Audhya, Paul ;

Coyne, Daniel ;

Garimella, Tushar ;

Parving, Hans-Henrik ;

Pritchett, Yili ;

Remuzzi, Giuseppe ;

Ritz, Eberhard ;

Andress, Dennis .

LANCET, 2010, 376 (9752) :1543-1551

[8] Vitamin D status and clinical outcomes in incident dialysis patients: results from the NECOSAD study [J].

Drechsler, Christiane ;

Verduijn, Marion ;

Pilz, Stefan ;

Dekker, Friedo W. ;

Krediet, Raymond T. ;

Ritz, Eberhard ;

Wanner, Christoph ;

Boeschoten, Elisabeth W. ;

Brandenburg, Vincent .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2011, 26 (03) :1024-1032

[9] NONCALCEMIC ACTIONS OF 1,25-DIHYDROXYVITAMIN D-3 AND CLINICAL-APPLICATIONS [J].

HOLICK, MF .

BONE, 1995, 17 (02) :S107-S111

[10] ETHNIC VARIATION IN VITAMIN-D-BINDING PROTEIN (GC) - A REVIEW OF ISOELECTRIC-FOCUSING STUDIES IN HUMAN-POPULATIONS [J].

KAMBOH, MI ;

FERRELL, RE .

HUMAN GENETICS, 1986, 72 (04) :281-293

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