Stereoselective Synthesis of the Antileukemic Sesquiterpene (+)-Caparratriene from L-menthol and Tiglic Aldehyde

被引：5

作者：

Vydrina, V. A. ^{[1
]}

Kravchenko, A. A. ^{[1
]}

Yakovleva, M. P. ^{[1
]}

Ishmuratova, N. M. ^{[1
]}

Ishmuratov, G. Yu. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, 71 Prosp Oktyabrya, Ufa 450054, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2018年 / 54卷 / 03期

关键词：

(+)-caparratriene; L-menthol; tiglic aldehyde; Wittig reaction; (R)-(-)-citronellylbromide;

D O I：

10.1007/s10600-018-2379-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stereoselective synthesis of natural (+)-caparratriene was developed starting from commercially available L-menthol and tiglic aldehyde. The key step was a Wittig reaction of the latter with the triphenylphosphorane generated from (R)-(-)-citronellyl bromide. (+)-Caparratriene as a mixture (4:1) of 2E,4E- and 2E,4Z-stereoisomers is a known anticancer agent.

引用

页码：461 / 463

页数：3

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