Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study

被引：25

作者：

Aoyama, Yoshiyuki ^{[1
]}

Hanaoka, Naoki ^{[2
]}

Kameyama, Masaki ^{[1
]}

Suda, Masashi ^{[1
]}

Sato, Toshimasa ^{[1
]}

Song, Mingqiao ^{[1
]}

Fukuda, Masato ^{[1
]}

Mikuni, Masahiko ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Psychiat & Human Behav, Gunma 3718511, Japan

[2] Sanmaibashi Hosp, Dept Psychiat, Ota Ku, Gunma 3730054, Japan

来源：

NEUROSCIENCE RESEARCH | 2009年 / 63卷 / 01期

关键词：

rTMS; Near-infrared spectroscopy; Hemoglobin concentration; Depression; Magnetic stimulation; Therapy; TRANSCRANIAL MAGNETIC STIMULATION; DOUBLE-BLIND; DEPRESSED-PATIENTS; MAJOR DEPRESSION; RESISTANT DEPRESSION; PREFRONTAL CORTEX; CONTROLLED-TRIAL; MOTOR CORTEX; BOLD-FMRI; TMS;

D O I：

10.1016/j.neures.2008.10.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repetitive transcranial magnetic stimulation (rTMS) has recently been widely employed for the investigation of brain function and treatment of psychiatric and neurological disorders. Although high and low Stimulation frequencies are assumed to activate and deactivate brain function, respectively, the optimal parameters of rTMS for treatment of depression have been determined only on the basis of their clinical efficacy. In this Study, we administered a 60-s low-frequency rTMS of three grades low intensities over the right dorsolateral prefrontal cortex (DLPFC) in 10 healthy Volunteers, and monitored functional changes of the contralateral DLPFC by near-infrared spectroscopy (NIRS) during and immediately after rTMS. Obtained results demonstrated significant [oxy-Hb] decreases during rTMS, and significant differences in the time courses of [oxy-Hb] changes among three stimulus intensities, that is, [oxy-Hb] decreases were most prominent during the latter half of the Stimulation and the first 30 S of poststimulation only at 15 mm condition (58% intensity). These results suggest that monitoring of brain functional changes due to rTMS using NIRS is useful for elucidating the brain mechanisms underlying the clinical effects of rTMS, and the effects of rTMS over contralateral DLPFC are obtained if the Stimulus intensities are more than one-half of the motor thresholds. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：47 / 51

页数：5

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