A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies

被引：55

作者：

Olive, C

Batzloff, MR

Horváth, A

Wong, A

Clair, T

Yarwood, P

Toth, I

Good, MF

机构：

[1] Queensland Inst Med Res, Div Infect Dis & Immunol, Cooperat Res Ctr Vaccine Technol, Brisbane, Qld 4029, Australia

[2] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 05期

关键词：

D O I：

10.1128/IAI.70.5.2734-2738.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The study reported here investigated the immunogenicity and protective potential of a lipid core peptide (LCP) construct containing a conserved region determinant of M protein, defined as peptide J8. Parenteral immunization of mice with LCP-J8 led to the induction of high-titer serum immunoglobulin G J18-specific antibodies when the construct was coadministered with complete Freund's adjuvant (CFA) or administered alone. LCP-J8 in CFA had significantly enhanced immunogenicity compared with the monomeric peptide J8 given in CFA. Moreover, LCP-J8/CFA and LCP-J8 antisera opsonized four different group A streptococcal (GAS) strains, and the antisera did not cross-react with human heart tissue proteins. These data indicate the potential of an LCP-based M protein conserved region GAS vaccine in the induction of broadly protective immune responses in the absence of a conventional adjuvant.

引用

页码：2734 / 2738

页数：5

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