Translating tolerogenic therapies to the clinic - where do we stand?

被引：26

作者：

Issa, Fadi ^{[1
]}

Wood, kathryn J. ^{[1
]}

机构：

[1] Univ Oxford, Transplantat Res Immunol Grp, Nuffield Dept Surg Sci, John Radcliffe Hosp, Oxford OX3 9DU, England

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

tolerance; immune regulation; cellular therapy; chimerism; regulatory T cell; clinical trials; transplantation;

D O I：

10.3389/fimmu.2012.00254

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation. A number of experimental techniques exploiting central and peripheral tolerance mechanisms have demonstrated success, leading to the first early phase clinical trials for tolerance induction. The first major strategy centers on the facilitation of donor-cell mixed chimensm in the transplant recipient with the use of bone marrow or hematopoietic stem cell transplantation. The second strategy, utilizing peripheral regulatory mechanisms, focuses on cellular therapy with regulatory T cells. This review examines the key studies and novel research directions in the field of immunological tolerance.

引用

页数：14

共 189 条

[21] The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation [J].

Bluestone, J. A. ;

Liu, W. ;

Yabu, J. M. ;

Laszik, Z. G. ;

Putnam, A. ;

Belingheri, M. ;

Gross, D. M. ;

Townsend, R. M. ;

Vincenti, F. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (10) :2086-2096

[22] Myeloid-derived suppressor cells: Natural regulators for transplant tolerance [J].

Boros, Peter ;

Ochando, Jordi C. ;

Chen, Shu-Hsia ;

Bromberg, Jonathan S. .

HUMAN IMMUNOLOGY, 2010, 71 (11) :1061-1066

[23] Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis [J].

Brandt, C. ;

Pavlovic, V. ;

Radbruch, A. ;

Worm, M. ;

Baumgrass, R. .

ALLERGY, 2009, 64 (11) :1588-1596

[24] Whole Blood Flow Cytometric Measurement of NFATc1 and IL-2 Expression to Analyze Cyclosporine A-Mediated Effects in T Cells [J].

Brandt, Claudia ;

Liman, Peter ;

Bendfeldt, Hanna ;

Mueller, Karin ;

Reinke, Petra ;

Radbruch, Andreas ;

Worm, Margitta ;

Baumgrass, Ria .

CYTOMETRY PART A, 2010, 77A (07) :607-613

[25] The impact of memory T cells on rejection and the induction of tolerance [J].

Brook, Matthew O. ;

Wood, Kathryn J. ;

Jones, Nick D. .

TRANSPLANTATION, 2006, 82 (01) :1-9

[26] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

[27] Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics [J].

Brunstein, Claudio G. ;

Miller, Jeffrey S. ;

Cao, Qing ;

McKenna, David H. ;

Hippen, Keli L. ;

Curtsinger, Julie ;

DeFor, Todd ;

Levine, Bruce L. ;

June, Carl H. ;

Rubinstein, Pablo ;

McGlave, Philip B. ;

Blazar, Bruce R. ;

Wagner, John E. .

BLOOD, 2011, 117 (03) :1061-1070

[28] Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease [J].

Bühler, LH ;

Spitzer, TR ;

Sykes, M ;

Sachs, DH ;

Delmonico, FL ;

Tolkoff-Rubin, N ;

Saidman, SL ;

Sackstein, R ;

McAfee, S ;

Dey, B ;

Colby, C ;

Cosimi, AB .

TRANSPLANTATION, 2002, 74 (10) :1405-1409

[29] IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells [J].

Burchill, Matthew A. ;

Yang, Jianying ;

Vogtenhuber, Christine ;

Blazar, Bruce R. ;

Farrar, Michael A. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (01) :280-290

[30] INDUCTION OF OPERATIONAL TOLERANCE BY RANDOM BLOOD-TRANSFUSION COMBINED WITH ANTI-CD4 ANTIBODY THERAPY - A PROTOCOL WITH SIGNIFICANT CLINICAL POTENTIAL [J].

BUSHELL, A ;

MORRIS, PJ ;

WOOD, KJ .

TRANSPLANTATION, 1994, 58 (02) :133-139

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