Translating tolerogenic therapies to the clinic - where do we stand?

被引：26

作者：

Issa, Fadi ^{[1
]}

Wood, kathryn J. ^{[1
]}

机构：

[1] Univ Oxford, Transplantat Res Immunol Grp, Nuffield Dept Surg Sci, John Radcliffe Hosp, Oxford OX3 9DU, England

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

tolerance; immune regulation; cellular therapy; chimerism; regulatory T cell; clinical trials; transplantation;

D O I：

10.3389/fimmu.2012.00254

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation. A number of experimental techniques exploiting central and peripheral tolerance mechanisms have demonstrated success, leading to the first early phase clinical trials for tolerance induction. The first major strategy centers on the facilitation of donor-cell mixed chimensm in the transplant recipient with the use of bone marrow or hematopoietic stem cell transplantation. The second strategy, utilizing peripheral regulatory mechanisms, focuses on cellular therapy with regulatory T cells. This review examines the key studies and novel research directions in the field of immunological tolerance.

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页数：14

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