Determination of Paracetamol in Presence of Ascorbic Acid in Pharmaceutical Products by Scanning Electrochemical Microscopy

被引：4
作者：
Lima, Alex S. [1 ]
Meloni, Gabriel N. [1 ]
Bertotti, Mauro [1 ]
机构：
[1] Univ Sao Paulo, Inst Quim, BR-09500900 Sao Paulo, Brazil
来源：
ELECTROANALYSIS | 2013年 / 25卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
Ascorbic acid; Paracetamol; Scanning electrochemical microscopy; Microelectrodes; SPECTROPHOTOMETRIC DETERMINATION; GLUCOSE; ACETAMINOPHEN; ELECTRODE;
D O I：
10.1002/elan.201300055
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The selective amperometric determination of paracetamol in pharmaceutical formulations containing ascorbate was achieved by removing the interfering species in the diffusion layer created between a platinum substrate and a disc microelectrode in a Scanning Electrochemical Microscopy (SECM) configuration, while the target analyte was kept unconsumed. After complete depletion of ascorbate, paracetamol was detected at the SECM tip in a free-interference solution zone. The influence of the substrate potential and the gap distance on the efficiency of ascorbate removal was systematically examined. The effectiveness of the device towards the determination of paracetamol in pharmaceutical samples was evaluated and under optimal conditions the results obtained agreed well with the labeled value.
引用
收藏
页码：1395 / 1399
页数：5
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