Determination of Paracetamol in Presence of Ascorbic Acid in Pharmaceutical Products by Scanning Electrochemical Microscopy

被引：4
|
作者：
Lima, Alex S. [1 ]
Meloni, Gabriel N. [1 ]
Bertotti, Mauro [1 ]
机构：
[1] Univ Sao Paulo, Inst Quim, BR-09500900 Sao Paulo, Brazil
来源：
ELECTROANALYSIS | 2013年 / 25卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
Ascorbic acid; Paracetamol; Scanning electrochemical microscopy; Microelectrodes; SPECTROPHOTOMETRIC DETERMINATION; GLUCOSE; ACETAMINOPHEN; ELECTRODE;
D O I：
10.1002/elan.201300055
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The selective amperometric determination of paracetamol in pharmaceutical formulations containing ascorbate was achieved by removing the interfering species in the diffusion layer created between a platinum substrate and a disc microelectrode in a Scanning Electrochemical Microscopy (SECM) configuration, while the target analyte was kept unconsumed. After complete depletion of ascorbate, paracetamol was detected at the SECM tip in a free-interference solution zone. The influence of the substrate potential and the gap distance on the efficiency of ascorbate removal was systematically examined. The effectiveness of the device towards the determination of paracetamol in pharmaceutical samples was evaluated and under optimal conditions the results obtained agreed well with the labeled value.
引用
收藏
页码：1395 / 1399
页数：5
相关论文
共 50 条
  • [21] Electrochemical behavior of ascorbic acid and uric acid in the presence of micelles and their selective determination application
    Gao, Z. -N.
    Peng, J.
    Han, X. -X.
    POLISH JOURNAL OF CHEMISTRY, 2007, 81 (03) : 441 - 454
  • [22] Flavin mononucleotide-exfoliated graphene flakes as electrodes for the electrochemical determination of uric acid in the presence of ascorbic acid
    Abellan-Llobregat, A.
    Ayan-Varela, M.
    Vidal, L.
    Paredes, J. I.
    Villar-Rodil, S.
    Canals, A.
    Morallon, E.
    JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2016, 783 : 41 - 48
  • [23] Simultaneous Determination of Acetaminophen (Paracetamol) and Ascorbic Acid in Pharmaceutical Formulations by LC Coupled to a Screen Printed Carbon Based Amperometric Detector
    Sarakbi, Ahmad
    Aydogmus, Zeynep
    Sidali, Tarik
    Gokce, Gultekin
    Kauffmann, Jean-Michel
    ELECTROANALYSIS, 2011, 23 (01) : 29 - 36
  • [24] Electrochemical Determination of Paracetamol in Blood and Pharmaceutical Formulations Using Activated Carbon Electrode
    Laghrib, F.
    Hammani, H.
    Farahi, A.
    Lahrich, S.
    Aboulkas, A.
    El Mhammedi, M. A.
    RUSSIAN JOURNAL OF ELECTROCHEMISTRY, 2021, 57 (05) : 532 - 543
  • [25] Electrochemical Determination of Epinephrine with a Pyrolytic Graphite Electrode in the Presence of Ascorbic Acid and Dopamine
    Xiu Hui LIU
    Chinese Chemical Letters, 2006, (05) : 657 - 660
  • [26] Nanostructured based Electrochemical Sensor for Voltammetric Determination of Ascorbic Acid in Pharmaceutical and Biological Samples
    Beitollahi, Hadi
    Tajik, Somayeh
    Parvan, Hekmat
    Soltani, Hossein
    Akbari, Ali
    Asadi, Malek Hossein
    ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY, 2014, 6 (01): : 54 - 66
  • [27] Electrochemical determination of epinephrine with a pyrolytic graphite electrode in the presence of ascorbic acid and dopamine
    Liu, Xiu Hui
    Zhang, Yan
    Zuo, Guo Fang
    Lu, Xiao Quan
    CHINESE CHEMICAL LETTERS, 2006, 17 (05) : 657 - 660
  • [28] Flow System with Electrochemical Detection for Determination of Paracetamol in Pharmaceutical Preparations
    Silva, M. L. S.
    Garcia, M. B. Q.
    Lima, J. L. F. C.
    Barrado, E.
    PORTUGALIAE ELECTROCHIMICA ACTA, 2006, 24 (02) : 261 - 271
  • [29] Electrochemical methods for ascorbic acid determination
    Pisoschi, Aurelia Magdalena
    Pop, Aneta
    Serban, Andreea Iren
    Fafaneata, Cornelia
    ELECTROCHIMICA ACTA, 2014, 121 : 443 - 460
  • [30] In situ electrochemical synthesis of highly loaded zirconium nanoparticles decorated reduced graphene oxide for the selective determination of dopamine and paracetamol in presence of ascorbic acid
    Vilian, A. T. Ezhil
    Rajkumar, Muniyandi
    Chen, Shen-Ming
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 115 : 295 - 301
12345