Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins

被引:48
作者
Cai, Anping [1 ]
Zhou, Yingling [1 ]
Li, Liwen [1 ]
机构
[1] Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangdong Gen Hosp, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China
来源
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2015年 / 4卷 / 07期
关键词
atherosclerotic cardiovascular diseases; Rho-GTPase; statins; NITRIC-OXIDE SYNTHASE; HMG-COA REDUCTASE; HUMAN ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; ACUTE MYOCARDIAL-INFARCTION; INDUCED DOWN-REGULATION; PROTEIN-KINASE; CARDIAC-HYPERTROPHY; THERAPEUTIC TARGET;
D O I
10.1161/JAHA.115.002113
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:9
相关论文
共 95 条
[81]   Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ [J].
Wagner, AH ;
Schwabe, O ;
Hecker, M .
BRITISH JOURNAL OF PHARMACOLOGY, 2002, 136 (01) :143-149
[82]   Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice [J].
Wang, Hong-Wei ;
Liu, Ping-Yen ;
Oyama, Naotsugu ;
Rikitake, Yoshiyuki ;
Kitamoto, Shiro ;
Gitlin, Jonathan ;
Liao, James K. ;
Boisvert, William A. .
FASEB JOURNAL, 2008, 22 (10) :3561-3570
[83]   ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells [J].
Wang, Yuepeng ;
Zheng, Xiaoyu Rayne ;
Riddick, Nadeene ;
Bryden, Meredith ;
Baur, Wendy ;
Zhang, Xin ;
Surks, Howard K. .
CIRCULATION RESEARCH, 2009, 104 (04) :531-U226
[84]   Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells:: Involvement of angiotensin AT1 receptor expression and Rac1 GTPase [J].
Wassmann, S ;
Laufs, U ;
Bäumer, AT ;
Müller, K ;
Konkol, C ;
Sauer, H ;
Böhm, M ;
Nickenig, G .
MOLECULAR PHARMACOLOGY, 2001, 59 (03) :646-654
[85]   Effects of atorvastatin on stroke in patients with unstable angina or non-Q-wave myocardial infarction - A myocardial ischemia reduction with aggressive cholesterol lowering (MIRACL) substudy [J].
Waters, DD ;
Schwartz, GG ;
Olsson, AG ;
Zeiher, A ;
Oliver, MF ;
Ganz, P ;
Ezekowitz, M ;
Chaitman, BR ;
Leslie, SJ ;
Stem, T .
CIRCULATION, 2002, 106 (13) :1690-1695
[86]   Statins have biphasic effects on angiogenesis [J].
Weis, M ;
Heeschen, C ;
Glassford, AJ ;
Cooke, JP .
CIRCULATION, 2002, 105 (06) :739-745
[87]  
Weissberg PL, 1999, NEW ENGL J MED, V340, P1928
[88]   Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1 [J].
Wirth, A ;
Schroeter, M ;
Kock-Hauser, C ;
Manser, E ;
Chalovich, JM ;
de Lanerolle, P ;
Pfitzer, G .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 549 (02) :489-500
[89]   Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering [J].
Wójciak-Stothard, B ;
Williams, L ;
Ridley, AJ .
JOURNAL OF CELL BIOLOGY, 1999, 145 (06) :1293-1307
[90]  
Wójciak-Stothard B, 1998, J CELL PHYSIOL, V176, P150, DOI 10.1002/(SICI)1097-4652(199807)176:1<150::AID-JCP17>3.0.CO