Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins

被引:48
作者
Cai, Anping [1 ]
Zhou, Yingling [1 ]
Li, Liwen [1 ]
机构
[1] Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangdong Gen Hosp, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China
来源
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2015年 / 4卷 / 07期
关键词
atherosclerotic cardiovascular diseases; Rho-GTPase; statins; NITRIC-OXIDE SYNTHASE; HMG-COA REDUCTASE; HUMAN ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; ACUTE MYOCARDIAL-INFARCTION; INDUCED DOWN-REGULATION; PROTEIN-KINASE; CARDIAC-HYPERTROPHY; THERAPEUTIC TARGET;
D O I
10.1161/JAHA.115.002113
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:9
相关论文
共 95 条
[1]   MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].
ALBERTS, AW ;
CHEN, J ;
KURON, G ;
HUNT, V ;
HUFF, J ;
HOFFMAN, C ;
ROTHROCK, J ;
LOPEZ, M ;
JOSHUA, H ;
HARRIS, E ;
PATCHETT, A ;
MONAGHAN, R ;
CURRIE, S ;
STAPLEY, E ;
ALBERSSCHONBERG, G ;
HENSENS, O ;
HIRSHFIELD, J ;
HOOGSTEEN, K ;
LIESCH, J ;
SPRINGER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961
[2]   A role for Cdc42 in macrophage chemotaxis [J].
Allen, WE ;
Zicha, D ;
Ridley, AJ ;
Jones, GE .
JOURNAL OF CELL BIOLOGY, 1998, 141 (05) :1147-1157
[3]   Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition [J].
Argmann, CA ;
Edwards, JY ;
Sawyez, CG ;
O'Neil, CH ;
Hegele, RA ;
Pickering, JG ;
Huff, MW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) :22212-22221
[4]   Rho GTPases in platelet function [J].
Aslan, J. E. ;
Mccarty, O. J. T. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (01) :35-46
[5]   p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI-Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear [J].
Aslan, Joseph E. ;
Itakura, Asako ;
Haley, Kristina M. ;
Tormoen, Garth W. ;
Loren, Cassandra P. ;
Baker, Sandra M. ;
Pang, Jiaqing ;
Chernoff, Jonathan ;
McCarty, Owen J. T. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (07) :1544-1551
[6]   Involvement of geranylgeranylation of Rho and Rac GTPases in adipogenic and RANKL expression, which was inhibited by simvastatin [J].
Baba, T. T. ;
Ohara-Nemoto, Y. ;
Miyazaki, T. ;
Nemoto, T. K. .
CELL BIOCHEMISTRY AND FUNCTION, 2013, 31 (08) :652-659
[7]   Atorvastatin inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells [J].
Bao, Xiao-mei ;
Wu, Chun-fang ;
Lu, Guo-ping .
ACTA PHARMACOLOGICA SINICA, 2010, 31 (04) :476-484
[8]   BIOSYNTHESIS AND CHARACTERIZATION OF (S) AND (R)-3-HYDROXY-3-METHYLGLUTARYL COENZYME-A [J].
BISCHOFF, KM ;
RODWELL, VW .
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1992, 48 (02) :149-158
[9]   Statin treatment and new-onset diabetes: A review of proposed mechanisms [J].
Brault, Marilyne ;
Ray, Jessica ;
Gomez, Yessica-Haydee ;
Mantzoros, Christos S. ;
Daskalopoulou, Stella S. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (06) :735-745
[10]   Cell cycle progression - New therapeutic target for vascular proliferative disease [J].
Braun-Dullaeus, RC ;
Mann, MJ ;
Dzau, VJ .
CIRCULATION, 1998, 98 (01) :82-89