Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection

被引：72

作者：

Hamelin, ME

Prince, GA

Boivin, G

机构：

[1] CHUQ, CHUL, Res Ctr Infect Dis, Ste Foy, PQ G1V 4G2, Canada

[2] Univ Laval, Quebec City, PQ G1K 7P4, Canada

[3] Vir Syst Inc, Rockville, MD USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 02期

关键词：

D O I：

10.1128/AAC.50.2.774-777.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log(10)) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.

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收藏

页码：774 / 777

页数：4

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