Soy isoflavone intake and risk of cardiovascular disease in adults: A systematic review and dose-response meta-analysis of prospective cohort studies

被引：9

作者：

Naghshi, Sina ^{[1
,2
]}

Tutunchi, Helda ^{[3
]}

Yousefi, Mojtaba ^{[4
]}

Naeini, Fatemeh ^{[2
]}

Mobarak, Sara ^{[5
]}

Asadi, Masoomeh ^{[6
]}

Sadeghi, Omid ^{[7
,8
]}

机构：

[1] Tabriz Univ Med Sci, Student Res Comm, Nutr Res Ctr, Sch Nutr & Food Sci, Tabriz, Iran

[2] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran

[3] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran

[4] Yasuj Univ Med Sci, Sch Hlth & Nutr, Dept Nutr, Yasuj, Iran

[5] Abadan Univ Med Sci, Abadan, Iran

[6] Abadan Univ Med Sci, Dept Operating Room Nursing, Abadan, Iran

[7] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran

[8] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2024年 / 64卷 / 18期

关键词：

Cardiovascular disease; isoflavone; meta-analysis; soy; stroke; CORONARY-HEART-DISEASE; FLAVONOID INTAKE; TREND ESTIMATION; DIETARY SOY; MORTALITY; HEALTH; ASSOCIATION; CONSUMPTION; STROKE;

D O I：

10.1080/10408398.2022.2163372

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We examined the association between soy isoflavone intake and risk of cardiovascular disease (CVD) outcomes in adults. We searched the online databases for relevant studies published up to September 2021. In total, 13 publications were included in the systematic review and 12 in the meta-analysis. We found that a high intake of soy isoflavones was significantly associated with a lower risk of coronary heart disease (CHD) among whole populations (Pooled RR: 0.92, 95% CI: 0.85-0.99, I-2 = 41.0%, P-heterogeneity = 0.10) and a lower risk of overall CVD (Pooled RR: 0.91, 95% CI: 0.84-0.98, I-2 = 30.7%, P-heterogeneity = 0.19) and CHD (Pooled RR: 0.89, 95% CI: 0.83-0.96, I-2 = 14.4%, P-heterogeneity = 0.32) among Western population. In the linear dose-response analysis, a 3 mg/day increase in soy isoflavone intake was associated with 16% and 14% lower risks of overall CVD and CHD, respectively, among Western population. In conclusion, we found that soy isoflavone intake was associated with a lower risk of overall CVD and CHD in adults, particularly among Western population.

引用

页码：6087 / 6101

页数：15

共 46 条

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