Galleria mellonella Larvae as an Infection Model for Penicillium marneffei

被引：15

作者：

Huang, Xiaowen ^{[1
,2
]}

Li, Dedong ^{[2
,3
]}

Xi, Liyan ^{[1
]}

Mylonakis, Eleftherios ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Dermatol, Guangzhou 510275, Guangdong, Peoples R China

[2] Brown Univ, Rhode Isl Hosp, Div Infect Dis, Warren Alpert Med Sch, Providence, RI 02903 USA

[3] Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Beijing, Peoples R China

来源：

MYCOPATHOLOGIA | 2015年 / 180卷 / 3-4期

基金：

中国国家自然科学基金;

关键词：

Penicillium marneffei; Galleria mellonella; Infection model; ASPERGILLUS-FUMIGATUS; FUNGAL PATHOGENESIS; INSECT MODEL; HOST; VIRULENCE; CANDIDA; MORPHOGENESIS; SYSTEM; YEAST;

D O I：

10.1007/s11046-015-9897-y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Penicillium marneffei, the only known dimorphic and pathogenic species in the genus of Penicillium, is responsible for severe to deadly infection in immunocompromised patients. In this study, P. marneffei was able to infect the greater wax moth Galleria mellonella. The increasing inoculum doses of P. marneffei cells resulted in greater larval mortality, and the larval mortality rate also depended on the incubation temperature after P. marneffei infection and different P. marneffei strains. Moreover, the phagocytosis of hemocytes to P. marneffei was investigated, and it showed that the phagocytosis was increasing during the infection. These results demonstrated that G. mellonella can be effectively used to facilitate the in vivo study of P. marneffei infection and hemocytes are the key component of the larvae's immune defenses.

引用

页码：159 / 164

页数：6

共 25 条

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